14675-44-6

Basic information

• Product Name: (1,4-DIMETHYL-2-PIPERAZINYL)METHANOL
• Synonyms: BUTTPARK 94\04-99;(1,4-DIMETHYLPIPERAZIN-2-YL)METHANOL;(1,4-DIMETHYL-2-PIPERAZINYL)METHANOL;1,4-DIMETHYL-2-(HYDROXYMETHYL)PIPERAZINE;2-PIPERAZINEMETHANOL,1,4-DIMETHYL;1,4-Dimethylpiperazine-2-methanol
• CAS NO: 14675-44-6
• Molecular Formula: C₇H₁₆N₂O
• Molecular Weight: 144.21
• Product Categories: Hydroxymethyl's;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 14675-44-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 110-112°C 13mm
• Flash Point: 70.3 °C
• Appearance: /
• Density: 0.98 g/cm³
• Vapor Pressure: 0.108mmHg at 25°C
• Refractive Index: 1.472
• CAS DataBase Reference: (1,4-DIMETHYL-2-PIPERAZINYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1,4-DIMETHYL-2-PIPERAZINYL)METHANOL(14675-44-6)
• EPA Substance Registry System: (1,4-DIMETHYL-2-PIPERAZINYL)METHANOL(14675-44-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 14675-44-6(Hazardous Substances Data)

Usage

General Description

(1,4-DIMETHYL-2-PIPERAZINYL)METHANOL, also known as piperazine, is a chemical compound with a piperazine ring and a hydroxyethyl group attached to it. It is widely used as a pharmaceutical intermediate and in the synthesis of various medications, including antipsychotics, antihistamines, and antimalarial drugs. Piperazine is also used as a corrosion inhibitor, a polymerization catalyst, and a precursor to other organic compounds. It is a versatile and valuable chemical with diverse applications in the pharmaceutical and chemical industries. However, it is important to handle and use piperazine with caution, as it can be harmful if ingested, inhaled, or in contact with skin.

InChI:InChI=1/C7H16N2O/c1-8-3-4-9(2)7(5-8)6-10/h7,10H,3-6H2,1-2H3

Upstream product

• 3674-13-3 2,3-dibromopropionic acid ethyl ester 
• 110-70-3 N,N`-dimethylethylenediamine 
• 96-13-9 2,3-Dibromopropan-1-ol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 106-89-8 epichlorohydrin 

Downstream Products

• 911223-09-1 2-(1,4-dimethyl-piperazin-2-ylmethoxy)-5-methyl-phenylamine 
• 1159598-55-6 (1,4-dimethylpiperazin-2-yl)methyl 4-benzylpiperazine-1-carboxylate 
• 911223-08-0 1,4-dimethyl-2-(4-methyl-2-nitro-phenoxymethyl)-piperazine 

Relevant articles and documents

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Interaction of (α-Haloalkyl)thiiranes with Nucleophilic Reagents. II. Reaction of (α-Chloroalkyl)thiiranes and Epihalohydrins with N,N′-Dimethylethylenediamine

The (chloromethyl)thiirane reacts with N,N′-dimethylethylenediamine at heating in toluene to yield a mixture of 1,4-dimethylpiperazine-2-methanethiol and hexahydro-1,4-dimethyl-1,4-diazepine-6-thiol in 2: 1 ratio. The 2-methyl-2-(chloromethyl)thiirane under similar condition forms only the respective diazepine homolog in a low yield, while the diastereomers eritro- and threo-(1-chloroethyl)thiirans react stereospecifically to afford the corresponding eritro- and threo-α,1,4-trimethylpiperazine-2-methanethiols, and 2,2-dimethyl-3-(chloromethyl)thiirane does not react at all. The behavior of epihalohydrins in reaction with the N,N′-dimethylethylenediamine is similar to that of their thioanalogs. The specific features of these reactions are discussed from the viewpoint of the known competition between the intramolecular cyclization and nucleophilic opening of the cycle in unsymmetrically substituted thiiranes (oxiranes).