146764-79-6Relevant articles and documents
Synthesis of Perfragilin B, A Cytotoxic Isoquinoline Quinone Isolated from the Bryozoan Membranipora perfragilis
Park, Aeri,Schmitz, Francis J.
, p. 3983 - 3984 (1993)
The cytotoxic isoquinoline quinone perfragilin B (2), which was isolated from the bryozoan Membranipora perfragilis, has been synthesized.The key step involves a Diels-Alder reaction between a substituted 2-azabutadiene (4) and 2,3-bis(thiomethyl)-1,4-benzoquinone (6) to produce the isoquinoline skeleton.