14677-11-3Relevant academic research and scientific papers
Synthesis of 4-aryl-1H-1,2,3-triazoles through TBAF-catalyzed [3 + 2] cycloaddition of 2-aryl-1-nitroethenes with TMSN3 under solvent-free conditions
Amantini, David,Fringuelli, Francesco,Piermatti, Oriana,Pizzo, Ferdinando,Zunino, Ennio,Vaccaro, Luigi
, p. 6526 - 6529 (2005)
TBAF-catalyzed [3 + 2] cycloaddition reactions of 2-aryl-1-cyano- or 2-aryl-1-carbethoxy-1-nitroethenes 1 with TMSN3 under SFC allow the corresponding 4-aryl-5-cyano- or 4-aryl-5-carbethoxy-1H-1,2,3-triazoles 2 to be prepared under mild reactio
Synthesis method of NH-1,2,3-triazole compound
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Paragraph 0027, (2017/07/20)
The invention relates to a synthesis method of a NH-1,2,3-triazole compound. The synthesis method is characterized by comprising the following steps that aldehyde, a nitro compound, sodium azide, a solvent and an additive react for 1-8 hours through a one-pot method at the temperature of 80 DEG C to 150 DEG C, and after reacting is finished, NH-1,2,3-triazole can be prepared through aftertreatment. According to the synthesis method, aldehyde, the nitro compound and sodium azide which are cheap and easy to obtain are adopted as raw materials, and the NH-1,2,3-triazole compound can be conveniently prepared from the three components. Compared with an existing method, the method has the advantages that the raw materials are low in cost, simple and easy to obtain, operation is easy and convenient, and the reaction efficiency is high.
α-Haloacrylates as acceptors in the [3 + 2] cycloaddition reaction with NaN3: An expedient approach to N-unsubstituted 1,2,3-triazole-4-carboxylates
Augustine, John Kallikat,Boodappa, Chandrakantha,Venkatachaliah, Srinivasa
, p. 2280 - 2288 (2014/04/03)
An expedient synthesis of N-unsubstituted 1,2,3-triazole-4-carboxylates has been demonstrated through [3 + 2] cycloaddition of sodium azide with α-haloacrylates. The process is highly reliable and exhibits an unusually wide scope with respect to α-fluoro-
Amberlite IRA900F as a solid fluoride source for a variety of organic transformations under solvent-free conditions
Fringuelli, Francesco,Lanari, Daniela,Pizzo, Ferdinando,Vaccaro, Luigi
experimental part, p. 3928 - 3932 (2009/04/08)
We have reported that Amberlite IRA900F (Amb-F) is an efficient metal-free catalyst for the activation of Si-N and Si-O bonds and a mild base in a variety of organic transformations under solvent-free conditions, such as the addition of TMSN3 to (E)-2-aryl-1-cyano-1-nitroethenes, nitriles, α,β-unsaturated acids and their esters, and the addition of dimethylsilyl ketene acetal and ethyl nitroacetate to β-nitrostyrenes. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
REACTION OF ACETYLENE NITRILES WITH AZIDES
Vereshchagin, L. I.,Filippova, T. M.,Bol'shedovorskaya, R. L.,Gavrilov, L. D.,Pavlova, G. A.
, p. 128 - 132 (2007/10/02)
The addition of organic and inorganic azides to 3-phenylpropynenitrile and 4-phenyl-2-hydroxy-3-butynenitrile was investigated.It was shown that organic azides add to 3-phenylpropynenitrile exclusively at the triple bond.The reaction with aluminum azide takes place with the participation of the acetylene bond and the nitrile group.The reaction of 4-phenyl-2-hydroxy-3-butynenitrile with azides is accompanied by decomposition to phenylpropargylaldehyde with the subsequent formation of 4-formyl-1,2,3-triazole.The oxidation of 4-phenyl-2-hydroxy-3-butynenitrile withactive manganese dioxide with the simultaneous addition of the azides leads to the formation of 4-carboxy-5-phenyl-1,2,3-triazole.
