1467739-15-6Relevant articles and documents
Synthesis of new pyrimidinylaminobenzene derivatives and their antiproliferative activities against melanoma cell line
Kim, Hee Jin,Oh, Chang-Hyun,Yoo, Kyung Ho
, p. 2311 - 2316 (2013/09/24)
A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.