146797-45-7

Upstream product

• 136347-10-9 (S₂,R_S)-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile 
• 4390-96-9 2-ethylacryloyl chloride 
• 764723-47-9 (S)-1-(2-methylenebutanoyl)pyrrolidine-2-carboxylic acid 
• 869735-53-5 (S)-2-bromomethyl-2-hydroxybutanoic acid 
• 869735-54-6 ethyl (S)-2-bromomethyl-2-hydroxybutanoate 
• 1369495-13-5 (R)-1-(2-methylenebutanoyl)pyrrolidine-2-carboxylic acid 
• 1369495-16-8 (3R,8aR)-3-(bromomethyl)-3-ethyltetrahydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,4(3H)-dione 
• 1250440-84-6 (R)-2-bromomethyl-2-hydroxybutanoic acid 
• 1369495-17-9 (R)-ethyl 2-bromomethyl-2-hydroxybutanoate 

Relevant academic research and scientific papers

Effective asymmetric synthesis of the key chiral building blocks of 20(S)- and 20(R)-camptothecins

An effective diastereoselective synthesis of (S)- N,N-diethyl-2-formyl-2- (methoxymethoxy)butanamide and (S)-2-formyl-2-(methoxymethoxy)butanoic acid ethyl ester, which are two key chiral building blocks for the synthesis of 20(S)-camptothecins, has been

A New General Method To Obtain Chiral 2-Alkylglycidyl Acid Derivatives: Synthesis of Methyl (R)-(+)-Palmoxirate

The hydrolysis of the diastereomerically pure cyanohydrins, obtained by reaction of Et2AlCN with homochiral α-sulfinyl ketones, yielded β-sulfenyl esters or amides, which evolved into the corresponding 2-alkylglycidic acid derivatives (ee >97percent) by treatment with Me3O(1+)BF4(1-) and NaHCO3.The use of this sequence to synthesize optically pure (R)-(+)-palmoxirate, a powerful hypoglicemic agent, is also described.