146803-42-1Relevant articles and documents
A solid-phase approach to mouse melanocortin receptor agonists derived from a novel thioether cyclized peptidomimetic scaffold
Bondebjerg, Jon,Xiang, Zhimin,Bauzo, Rayna M.,Haskell-Luevano, Carrie,Meldal, Morten
, p. 11046 - 11055 (2002)
The solid-phase synthesis of a novel thioether cyclized peptidomimetic scaffold, displaying functionality at the i to i + 3 positions, is reported. The thioether bridge is formed on-bead by an intramolecular reaction between a chloroacetylated reduced pep
Modulating Angiogenesis by Proteomimetics of Vascular Endothelial Growth Factor
Abdulkadir, Sami,Cai, Jianfeng,Hu, Yong,Jiang, Wei,Li, Chunpu,Li, Qi,Sang, Peng,Wei, Lulu,Zhao, Xue
supporting information, p. 270 - 281 (2022/01/19)
Angiogenesis, formation of new blood vessels from the existing vascular network, is a hallmark of cancer cells that leads to tumor vascular proliferation and metastasis. This process is mediated through the binding interaction of VEGF-A with VEGF receptor
α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions
Sang, Peng,Shi, Yan,Lu, Junhao,Chen, Lihong,Yang, Leixiang,Borcherds, Wade,Abdulkadir, Sami,Li, Qi,Daughdrill, Gary,Chen, Jiandong,Cai, Jianfeng
, p. 975 - 986 (2020/03/10)
The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein-protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be rationally designed to mimic the p53 α-helix and inhibit p53-MDM2 PPIs. The best
Synthesis and biological activity of peptide α-ketoamide derivatives as proteasome inhibitors
Pacifico, Salvatore,Ferretti, Valeria,Albanese, Valentina,Fantinati, Anna,Gallerani, Eleonora,Nicoli, Francesco,Gavioli, Riccardo,Zamberlan, Francesco,Preti, Delia,Marastoni, Mauro
, p. 1086 - 1092 (2019/08/01)
Proteasome activity affects cell cycle progression as well as the immune response, and it is largely recognized as an attractive pharmacological target for potential therapies against several diseases. Herein we present the synthesis of a series of pseudo