139551-83-0

Basic information

• Product Name: FMOC-L-LEUCINOL
• Synonyms: N-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINOL;N-ALPHA-FMOC-L-LEUCINOL;N-FMOC-L-LEUCINOL;FMOC-L-LEUCINOL;FMOC-LEU-OL;FMOC-LEUCINOL;FMOC-(S)-2-AMINO-4-METHYL-1-PENTANOL;FMOC-LEU-OL 98+%
• CAS NO: 139551-83-0
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.43
• Product Categories: Amino Acids;Amino Alcohols;Fmoc-Amino acid series
• Mol File: 139551-83-0.mol
• Article Data: 27

Chemical Properties

• Melting Point: 112-113 °C
• Boiling Point: 525.2 °C at 760 mmHg
• Flash Point: 271.4 °C
• Appearance: /
• Density: 1.148 g/cm³
• Storage Temp.: -15°C
• PKA: 11.48±0.46(Predicted)
• CAS DataBase Reference: FMOC-L-LEUCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-L-LEUCINOL(139551-83-0)
• EPA Substance Registry System: FMOC-L-LEUCINOL(139551-83-0)

Safety Data

• Hazardous Substances Data: 139551-83-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Fmoc-L-leucinol is an intermediate used in the preparation of Fmoc-protected amino azides from Fmoc-protected amino alcohols.

Upstream product

• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 329308-97-6 (9H-fluoren-9-yl)methyl 1-azido-4-methyl-1-oxopentan-2-ylcarbamate 
• 35661-60-0 Fmoc-Leu-OH 
• 76542-83-1 Fmoc-Leu-OSu 
• 1001439-29-7 C₂₄H₂₇NO₆ 
• 1072840-99-3 S-(9H-fluoren-9-yl)methyl 1-(1H-benzotriazol-1-yl)-4-methyl-1-oxopentan-2-ylcarbamate 
• 86060-88-0 N-(9-fluorenylmethoxycarbonyl)-L-leucine pentafluorophenyl ester 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 146803-42-1 N-(fluorenylmethyloxycarbonyl)-L-leucinal 
• 125814-21-3 (S)-4-Isobutyl-2,5-dioxo-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester 

Downstream Products

• 1252806-21-5 C₄₀H₄₅N₉O₈ 
• 1211530-34-5 C₂HF₃O₂*C₄₄H₈₁N₁₁O₁₁ 
• 391624-38-7 [2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentyl]-carbamic acid 4-nitro-phenyl ester 

Relevant articles and documents

A practical solid phase synthesis of oligopeptidosulfonamide foldamers

Oligopeptidosulfonamide foldamers were efficiently synthesized on the solid phase using Fmoc protected β-aminoethanesulfonylchlorides in the presence of N-methylmorpholine. (C) 2000 Elsevier Science Ltd.

A greener, efficient and catalyst-free ultrasonic-assisted protocol for the n-fmoc protection of amines

A simple, eco-sustainable method for the N-(9-fluorenylmethoxycarbonyl) (N-Fmoc) protection of various structurally amines under ultrasonic irradiation is reported. The corresponding N-Fmoc derivatives were obtained in good to excellent yields within short reaction time. The reaction proceeds without the formation of any side product. Mildness, efficiency and easier work are the main advantages of this new protocol.

Alzheimer's disease: Identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS)

The application of dynamic ligation screening (DLS), a methodology for fragment-based drug discovery (FBDD), to the aspartic protease β-secretase (BACE-1) is reported. For this purpose, three new fluorescence resonance energy transfer (FRET) substrates we