146830-21-9

Basic information

• Product Name: 2-(2',5'-dimethoxyphenyl)-5,8-dimethoxyquinoline
• Synonyms: 2-(2',5'-dimethoxyphenyl)-5,8-dimethoxyquinoline
• CAS NO: 146830-21-9
• Molecular Weight: 325.364
• Mol File: 146830-21-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2',5'-dimethoxyphenyl)-5,8-dimethoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2',5'-dimethoxyphenyl)-5,8-dimethoxyquinoline(146830-21-9)
• EPA Substance Registry System: 2-(2',5'-dimethoxyphenyl)-5,8-dimethoxyquinoline(146830-21-9)

Safety Data

• Hazardous Substances Data: 146830-21-9(Hazardous Substances Data)

Upstream product

• 1206-55-9 3,6-dimethoxy-2-nitrobenzaldehyde 
• 1201-38-3 2',5'-dimethoxyacetophenone 
• 126522-16-5 2-amino-3,6-dimethoxylbenzaldehyde 

Relevant articles and documents

Incorporation of Quinoline-5,8-quinone Moiety into Polyaza Cavities

Silica gel supported nitric acid treatment of 2,5-dimethoxybenzaldehyde followed by reduction with iron powder provides 3,6-dimethoxy-2-aminobenzaldehyde.Friedlaender condensation of this species with a variety of ketones and diketones leads to 5,8-dimethoxyquinoline derivatives which may be oxidized by ceric ammonium nitrate (CAN) and pyridine-2,6-dicarboxylic acid N-oxide (PDANO) to the corresponding quinones.The quinone functionality can be incorporated into larger cavities by a selective stepwise Friedlaender approach and the CAN/PDANO oxidation appears to work preferentially for 5,8-dimethoxyquinoline.