146846-56-2Relevant academic research and scientific papers
Nitro resin supported copper nanoparticles: An effective heterogeneous catalyst for [Formula presented] cross coupling and oxidative [Formula presented] homocoupling
Barot, Nirav,Patel, Sunil B.,Kaur, Harjinder
, p. 77 - 84 (2016)
In the present study, we investigate the synthesis and catalytic activity of copper nanoparticles (CuNPs) stabilized onto a novel nitro functionalized polystyrene resin. The deposited nanoparticles were characterized by various analytical techniques and TEM images, revealed uniformly distributed copper nanoparticles of sizes 3–9?nm. We effectively used the resin impregnated CuNPs for [Formula presented] coupling of various aromatic amines with aryl halides and for the oxidative [Formula presented] homocoupling of phenyacetylene. Further, recycling of the catalyst, leaching of metal ions and post reaction changes in the support were studied and it was concluded that the support acts as oxidant during the homocoupling of phenyl acetylene which is oxidative by nature.
Pseudo five-component synthesis of 2,5-di(hetero)arylthiophenes via a one-pot Sonogashira-Glaser cyclization sequence
Urselmann, Dominik,Antovic, Dragutin,Mueller, Thomas J. J.
supporting information; experimental part, p. 1499 - 1503 (2011/12/22)
Based upon a consecutive one-pot Sonogashira-Glaser coupling-cyclization sequence a variety of 2,5-di(hetero)arylthiophenes were synthesized in moderate to good yields. A single Pd/Cu-catalyst system, without further catalyst addition, and easily available, stable starting materials were used, resulting in a concise and highly efficient route for the synthesis of the title compounds. This novel pseudo five-component synthesis starting from iodo(hetero)arenes is particularly suitable as a direct access to well-defined thiophene oligomers, which are of peculiar interest in materials science.
Consecutive one-pot sonogashira-glaser coupling sequence- Direct preparation of symmetrical diynes by sequential Pd/Cu catalysis
Merkul, Eugen,Urselmann, Dominik,Mueller, Thomas J. J.
supporting information; experimental part, p. 238 - 242 (2011/03/20)
Sonogashira coupling and the catalytic Glaser coupling are both catalyzed by the Pd-Cu complex couple and can be concatenated to a consecutive sequentially Pd/Cu-catalyzed process in a one-pot fashion, and air oxygen serves as the only oxidant in the second step. In a pseudo-four-component synthesis, a broad variety of symmetrically substituted 1,4-bis(hetero)aryl-1,3-butadiynes are obtained in good to excellent yields. Interestingly, the presence of iodide ions has been found to be advantageous over other halides to trigger the Pd/Cu-catalyzed Glaser step, and Pd and Cu species, as well as triethylamine as a base, are prerequisite for both couplings, which proceed with higher efficiency if performed in a one-pot sequence. Two catalytic alkyne coupling reactions were combined in a consecutive sequentially Pd/Cu-catalyzed process to furnish a novel pseudo-four-component synthesis of a variety of symmetrically substituted 1,4-bis(hetero)aryl-1,3-butadiynes in goodyields. Pd and Cu species and triethylamine (base) are essential for the couplings, which proceed with higher efficiency if performed in a one-pot sequence. Copyright
