388061-72-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
3-(2-(triMethylsilyl)ethynyl)phenol is utilized as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, attributed to its wide range of applications in these fields. Its silyl-ethynyl group plays a crucial role in facilitating various organic transformations, thereby enhancing the compound's utility in creating new and effective drugs and agrochemicals.
Used as a Reagent in Chemical Reactions:
In the field of organic chemistry, 3-(2-(triMethylsilyl)ethynyl)phenol serves as a valuable reagent in a variety of chemical reactions. Its ability to participate in cross-coupling reactions and other organic transformations makes it an indispensable tool for chemists in their pursuit of novel chemical entities and processes.
Used in Material Development:
3-(2-(triMethylsilyl)ethynyl)phenol is also employed in the development of advanced materials such as polymers and coatings. Its unique chemical properties and reactivity contribute to the creation of innovative materials with enhanced performance characteristics, thereby expanding its applications across various industries.

Upstream product

• 626-02-8 3-Iodophenol 
• 1066-54-2 trimethylsilylacetylene 
• 591-20-8 3-Bromophenol 

Downstream Products

• 942202-08-6 1,4-bis(3-hydroxyphenyl)-1H-1,2,3-triazole 
• 1078733-86-4 3,3'-(thiophene-2,5-diyl)diphenol 
• 146846-56-2 3-(4-(3-hydroxyphenyl)buta-1,3-diynyl)phenol 
• 10401-10-2 3-(3-hydroxyphenyl)-2-propynoic acid 
• 128133-59-5 1-ethynyl-3-(phenylmethoxy)benzene 
• 1042149-62-1 C₁₇H₁₆O₄ 
• 937593-03-8 3-[(3-bromophenyl)ethynyl]phenol 

Relevant academic research and scientific papers

ANTIBACTERIAL ADJUVANTS AND APPLICATIONS THEREOF

In one aspect, compounds and methods are described herein for treating gram negative bacteria having resistance to cationic antimicrobial peptides. In some embodiments, for example, compounds of formula I are provided. In another aspect, a treatment for a gram negative bacterial infection comprises a cationic antimicrobial protein (CAP) in conjunction with a compound of formula I.

BTK Inhibitors and uses thereof

The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.

Design and synthesis of cyclic acylguanidines as BACE1 inhibitors

Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 11 exhibited a 14-fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD.

Aerobic oxynitration of alkynes with tBuONO and TEMPO

An efficient method for stereoselective nitroaminoxylation of alkyne has been reported. The reaction enjoys a broad substrate scope, good functional group tolerance, and high yields. Synthetically useful α-nitroketones can be accessed through these products in a single step.

HALOGEN-FREE FLAME RETARDING MATERIALS BASED ON BISPHENOL TRIAZOLE RESINS AND POLYMERS

The invention provides halogen-free, bisphenol triazole resins and polymers having exceptional flame retarding properties, related compositions and methods of making and use thereof.

Bisphenol-1,2,3-triazole (BPT) epoxies and cyanate esters: Synthesis and self-catalyzed curing

Novel bisphenol-1,2,3-triazole (BPT) resins, including epoxy (DGE-BPT) and cyanate ester (BPTCE) systems, were prepared and used in curing chemistry with no added reagents or catalysts. The materials were characterized relative to conventional epoxies and

Pseudo five-component synthesis of 2,5-di(hetero)arylthiophenes via a one-pot Sonogashira-Glaser cyclization sequence

Based upon a consecutive one-pot Sonogashira-Glaser coupling-cyclization sequence a variety of 2,5-di(hetero)arylthiophenes were synthesized in moderate to good yields. A single Pd/Cu-catalyst system, without further catalyst addition, and easily available, stable starting materials were used, resulting in a concise and highly efficient route for the synthesis of the title compounds. This novel pseudo five-component synthesis starting from iodo(hetero)arenes is particularly suitable as a direct access to well-defined thiophene oligomers, which are of peculiar interest in materials science.

Thermally induced structural transformation of bisphenol-1,2,3-triazole polymers: Smart, self-extinguishing materials

Safer plastics: A novel class of polymers, termed bisphenol-1,2,3-triazole (BPT) polyarylates, was prepared by polycondensation chemistry. They exhibit high-performance and self-extinguishing properties as a result of their heterocyclic nature and a therm

INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE)

The present invention includes insecticidal carbamates that are useful, for example, for the control of insects, such as mosquitoes, which can be used in applications where exposure to and/or contact with humans is likely. The insecticides of the present invention include phenyl N-methyl carbamates and compositions comprising them that exhibit species-selective inhibition of acetylcholinesterase (AChE) and are preferably toxic to mosquitoes but not humans. Of particular interest are compounds of Formula (I) and Formula (II): Compounds of Formula (I) and Formula (II) are especially suitable for insecticide treated nets and indoor residual spraying for mosquito control.

Linear free-energy correlation analysis of the electronic effects of the substituents in the Sonogashira coupling reaction

Relative rate constants (krel) for the Sonogashira coupling were determined in competitive reactions between iodobenzene and a series of para- and meta-substituted iodobenzenes and compared to the charge on iodine and the z-component of the qua