146863-02-7

Basic information

• Product Name: 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid
• Synonyms: 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid;(±)-1-Cyelopropyl-6-fluom-1，4-dihydro-5-methyl-7-(3-methyl-1-pipemzinyl)-4-oxo-3-quinolinecarboxylic acid;OPC-17116;Vaxar;1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid;1-Cyclopropyl-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid;Tomefloxacin;1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
• CAS NO: 146863-02-7
• Molecular Formula: C19H22FN3O3
• Molecular Weight: 0
• Mol File: 146863-02-7.mol

Chemical Properties

• Boiling Point: 610°C at 760 mmHg
• Flash Point: 322.7°C
• Appearance: /
• Density: 1.366g/cm³
• Vapor Pressure: 9.83E-16mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid(146863-02-7)
• EPA Substance Registry System: 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid(146863-02-7)

Safety Data

• Hazardous Substances Data: 146863-02-7(Hazardous Substances Data)

Usage

Chemical class

Quinolone class of antibacterial agents

Potential use

Treatment of bacterial infections

Functional groups

Cyclopropyl, fluoro, methyl, and piperazinyl

Antimicrobial activity

Broad spectrum

Mechanism of action

Inhibition of bacterial DNA replication process

Research status

Further research and clinical trials needed to evaluate efficacy and safety as a potential antibiotic agent

InChI:InChI=1/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26)

Upstream product

• 119915-46-7 ethyl 1-cyclopropyl-6,7-difluoro-5-methyl-4-oxoquinoline-3-carboxylate 
• 109-07-9 (RS)-2-methylpiperazine 
• 119916-34-6 1-cyclopropyl-6-fluoro-7-bromo-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 119915-47-8 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid 

Relevant articles and documents

Processes for the preparation of fluorinated benzoic acids

An object of the present invention is to provide a commercially advantageous process for preparing a fluoro benzoic acid. The process according to the present invention comprises either alkylating a fluoro benzoic acid of the formula wherein R1

Synthesis and Biological Activity of 5-Alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic Acids

A series of 5-alkyl-1,7,8-trisubstituted-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids was prepared and evaluated for in vitro and in vivo antibacterial activity.When compared to the 5-hydrogen analogues, the presence of the 5-methyl group enhanc

Benzoheterocyclic compounds

Novel 3-formyl-4-oxoquinoline compounds of the formula: STR1 wherein R1 is hydrogen atom or a lower alkanoyl, R2 is hydrogen atom or a lower alkyl, R3 is a lower alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

Antibacterial agents

Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the