146864-75-7Relevant articles and documents
First Total Syntheses of Tetracenomycins C and X
Sato, Shogo,Sakata, Keiichiro,Hashimoto, Yoshimitsu,Takikawa, Hiroshi,Suzuki, Keisuke
, p. 12608 - 12613 (2017)
The first total syntheses of tetracenomycins C and X were achieved, featuring 1) preparation of a hexasubstituted naphthonitrile oxide by successive benzyne cycloadditions and an oxidative ring-opening reaction; 2) a novel ortho-quinone mono-acetal as the A-ring unit; 3) construction of three contiguous stereogenic centers by an asymmetric benzoin cyclization, an isoxazole oxidation, and a stereoselective reduction.