146916-75-8

Upstream product

• 6089-04-9 3-(tetrahydropyran-2'-yloxy)propyne 
• 38996-32-6 5-(tetrahydropyran-2-yloxy)-3-pentyn-1-ol 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 146916-71-4 (3R,4S,5S)-3-Methoxy-5-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-dihydro-furan-2-one 
• 146916-80-5 (3R,4R,5S)-3-Hydroxy-5-[2-(4-methoxy-benzyloxy)-ethyl]-4-methyl-dihydro-furan-2-one 
• 146916-72-5 (4R,5S)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-4-methyl-dihydro-furan-2-one 
• 146916-73-6 (S)-5-((4-methoxybenzyl)oxy)pent-1-en-3-ol 
• 146986-42-7 ((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl) oxiran-2-yl)methanol 
• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 

Relevant academic research and scientific papers

Studies Directed Towards the Total Synthesis of Rhizoxin: Stereoselective Synthesis of C-12 to C-18 Segment

Chiral carbinol 5, made by a titanocene mediated ring opening of epoxy alcohol 11, was converted via an intramolecular radical cyclisation into a 'butanolide template' which was then transformed to the C-12 to C-18 segment 2 of rhizoxin (1). Key Words: Butanolide chiral template; Chiral carbinol; Intramolecular radical cyclisation; Vinyl Grignard reaction.