Studies Directed Towards the Total Synthesis of Rhizoxin: Stereoselective Synthesis of C-12 to C-18 Segment

Article abstract of DOI:10.1016/S0040-4039(00)61659-3

Chiral carbinol 5, made by a titanocene mediated ring opening of epoxy alcohol 11, was converted via an intramolecular radical cyclisation into a 'butanolide template' which was then transformed to the C-12 to C-18 segment 2 of rhizoxin (1). Key Words: Butanolide chiral template; Chiral carbinol; Intramolecular radical cyclisation; Vinyl Grignard reaction.