146936-47-2Relevant academic research and scientific papers
9-(SULFOXIMINOALKYL)GUANINE NUCLEOSIDES AS POTENTIAL ANTIHERPETIC AGENTS
Dolle, Roland E.,McNair, David
, p. 133 - 136 (2007/10/02)
A novel series of guanine nucleoside analogues 5-8 which contain a C-terminal sulfoximine have been synthesized.Key features of the synthesis include 1) the successful application of the trifluoroacetyl functional group as a stable, base-labile protecting group for the sulfoximine nitrogen and 2) the Mitsunobu-type coupling of alcohols 14 and 18-20 with purine 15.
