146941-12-0Relevant academic research and scientific papers
Oxazole Activation for Azomethine Ylide Trapping: Singly and Doubly Tethered Substrates
Vedejs, Edwin,Piotrowski, David W.
, p. 1341 - 1348 (1993)
Bicyclic oxazolium salts 18, 24, 37, and 44 can be generated from tethered haloalkyloxazoles by internal alkylation.Reductive alkylation of the oxazolium salts using CsF/PhSiH3 converts the salts initially into the corresponding 4-oxazoline derivatives.Su
A Heterogeneous Gold(I)-Catalyzed [2 + 2 + 1] Annulation of Terminal Alkynes, Nitriles, and Oxygen Atoms Leading to 2,5-Disubstituted Oxazoles
Yang, Weisen,Zhang, Rongli,Yi, Feiyan,Cai, Mingzhong
, p. 5204 - 5211 (2017/05/24)
The first heterogeneous gold(I)-catalyzed [2 + 2 + 1] annulation of terminal alkynes, nitriles, and oxygen atoms has been achieved by using an MCM-41-immobilized phosphine-gold(I) complex as catalyst and 8-methylquinoline N-oxide as oxidant under mild conditions, yielding a variety of 2,5-disubstituted oxazoles in good to excellent yields with broad substrate scope. The new heterogeneous gold(I) catalyst can easily be recovered by simple filtration of the reaction solution and recycled for at least eight times without significant loss of activity.
