146953-87-9Relevant academic research and scientific papers
Novel synthesis of N-unsubstituted imidazoles using N-trimethylsilylimines
Shih
, p. 595 - 598 (1993)
Cycloaddition of N-trimethylsilylimines 3 with the lithiotosylmethylisocyanates 4 is described. This provides a novel synthesis of 4-substituted and 4,5-disubstituted imidazoles from easily accessible aldehydes or organolithium reagents, under mild conditions and in a one-pot operation.
