146954-11-2Relevant academic research and scientific papers
Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation
Del Vecchio, Antonio,Talbot, Alex,Caillé, Fabien,Chevalier, Arnaud,Sallustrau, Antoine,Loreau, Olivier,Destro, Gianluca,Taran, Frédéric,Audisio, Davide
, p. 11677 - 11680 (2020)
A general procedure for the late-stage [11C], [13C] and [14C]carbon isotope labeling of cyclic carbamates is reported. This protocol allows the incorporation of carbon dioxide, the primary source of carbon-14 and carbon-11 radioisotopes, in a direct, cost-effective and sustainable manner. A disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.
Metal free carboamination of internal alkynes - An easy access to polysubstituted quinolines
Stopka,Niggemann
supporting information, p. 5761 - 5764 (2016/05/19)
A metal free carboamination of unactivated alkynes towards highly substituted quinolines was realized in the presence of a synergistic Br?nsted acid catalyst system. Supported by mechanistic probes, the reaction proceeds via a highly reactive vinyl cation in a C-C bond formation - Schmidt reaction sequence. The irreversible extrusion of N2, as a powerful driving force, allows for a general conversion of poorly nucleophilic aliphatic alkynes.
Synthetic Applications of Bis(iminophosphoranes). One-Pot Preparation of Rigid Bicyclic Guanidines
Molina, Pedro,Alajarin, Mateo,Vidal, Angel
, p. 1687 - 1695 (2007/10/02)
A one-pot synthesis of , , and bicyclic guanidines based on a new method of dihydropyrimido annelation, which involves reaction of bis(iminophosphoranes) with aryl isocyanates or isothiocyanates is described.The method is also applic
