146982-24-3

Basic information

• Product Name: FMOC-ASP(OALL)-OH
• Synonyms: N-ALPHA-FMOC-L-ASPARTIC ACID BETA-ALLYL ESTER;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID BETA ALLYL ESTER;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID BETA-ALLYL ESTER;FMOC-ASP(OAI)-OH;FMOC-ASP(OALL)-OH;FMOC-ASP(OALLYL)-OH;FMOC-ASP(OAL)-OH;FMOC-L-ASP(ALL)-OH
• CAS NO: 146982-24-3
• Molecular Formula: C₂₂H₂₁NO₆
• Molecular Weight: 395.41
• Product Categories: Amino Acids;Aspartic acid [Asp, D];Fmoc-Amino Acids and Derivatives;Fmoc-Asp
• Mol File: 146982-24-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 111-115 °C
• Boiling Point: 638.528 °C at 760 mmHg
• Flash Point: 339.97 °C
• Appearance: /Solid
• Density: 1.287 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• PKA: 3.59±0.23(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 6670219
• CAS DataBase Reference: FMOC-ASP(OALL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-ASP(OALL)-OH(146982-24-3)
• EPA Substance Registry System: FMOC-ASP(OALL)-OH(146982-24-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 146982-24-3(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

Fmoc-Asp(OAll)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

InChI:InChI=1/C22H21NO6/c1-2-11-28-20(24)12-19(21(25)26)23-22(27)29-13-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h2-10,18-19H,1,11-13H2,(H,23,27)(H,25,26)/t19-/m0/s1

Upstream product

• 1159497-08-1 C₂₅H₂₅NO₆ 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 123975-49-5 (S)-4-(allyloxy)-2-amino-4-oxobutanoic acid hydrochloride 

Downstream Products

• 207305-95-1 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-(1-methyl-1-phenyl-ethyl) ester 
• 207306-00-1 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 4-{2-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-ylsulfanyl]-ethyl} ester 1-(1-methyl-1-phenyl-ethyl) ester 
• 207306-05-6 C₅₄H₅₂N₂O₉S₁₆ 
• 1155867-00-7 Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-Lys]-NH₂ 
• 1155867-01-8 Ac-Nle-c[Asp-cis-4-guanidinyl-Pro-DPhe-Arg-Trp-Lys]-NH₂ 
• 1372404-33-5 EAFFD(All)D(All)VVLK 
• 1126433-33-7 H-Val-Lys-Asp-Val-Tyr-Ile-NH₂ 
• 207305-92-8 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 4-allyl ester 1-(1-methyl-1-phenyl-ethyl) ester 

Relevant articles and documents

A versatile and selective chemo-enzymatic synthesis of β-protected aspartic and γ-protected glutamic acid derivatives

Two versatile, high yielding, and efficient chemo-enzymatic methods for the synthesis of β-protected Asp and γ-protected Glu derivatives using Alcalase are described. The first method is based on the α-selective enzymatic hydrolysis of symmetrical aspartyl and glutamyl diesters. The second method involving mixed diesters comprises a three-step protocol using (i) α-selective enzymatic methyl-esterification, (ii) chemical β-esterification, and finally (iii) α-selective enzymatic methyl ester hydrolysis. The yields of the purified β- and γ-esters range from 77% to 91%.