244171-25-3Relevant academic research and scientific papers
Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor
Qu, Hongchang,Cai, Minying,Mayorov, Alexander V.,Grieco, Paolo,Zingsheim, Morgan,Trivedi, Dev,Hruby, Victor J.
, p. 3627 - 3635 (2009)
A new series of melanotropin analogues with His or Arg residues in the core pharmacophores of MTII, SHU9119, and Ac-NDP-γ-MSH-NH2 replaced by Pro or trans-/cis-4-guanidinyl-Pro derivatives were designed and synthesized to introduce selectivity
