146985-90-2

Upstream product

• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 105-58-8 Diethyl carbonate 
• 131472-79-2 (1S,2S)-1-phenyl-amino-3-O-tertbutyldimethylsilyloxy-1-propanol 
• 131472-78-1 (1S,2S)-2-[N-(diphenylmethylene)amino]-3-O-(tert-butyldimethylsilyl)-1-phenylpropane-1,3-diol 
• 131751-46-7 (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one 
• 155187-53-4 (4S,5S)-4-hydroxymethyl-5-phenyloxazolidine-2-thione 

Downstream Products

• 159415-80-2 (4S,5S)-4-tert-Butoxymethyl-5-phenyl-oxazolidin-2-one 
• 218766-18-8 Toluene-4-sulfonic acid (4S,5S)-2-oxo-5-phenyl-oxazolidin-4-ylmethyl ester 
• 159415-84-6 (4S,5S)-3-((E)-But-2-enoyl)-4-hydroxymethyl-5-phenyl-oxazolidin-2-one 
• 159415-81-3 (4S,5S)-3-((E)-But-2-enoyl)-4-tert-butoxymethyl-5-phenyl-oxazolidin-2-one 
• 1609551-15-6 (4S,5S)-4-((tert-butyldiphenylsilyloxy)methyl)-5-phenyloxazolidin-2-one 
• 109760-77-2 L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol 
• 218766-19-9 (4S,5S)-4-Morpholin-4-ylmethyl-5-phenyl-oxazolidin-2-one 
• 193545-66-3 (1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol 

Relevant academic research and scientific papers

Oxazolidin-2-one-Pyrimidine Derivatives

The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.

Glycosyltransferase inhibitors: Synthesis of D-threo-PDMP, L-threo- PDMP, and other brain glucosylceramide synthase inhibitors from D- or L- serine

The synthesis of enantiomerically pure (1S,2S)-1-phenyl-2- decanoylamino-3-N-morpholino-1-propanol (L-threo-PDMP) (1a) from L-serine, and the enantiomer (LR,2R)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP] (1b) from D-serine is reported. Reductive alkylation of the fully protected O'Donnell's Schiff base (3b) derived from D-serine provided the β-amino alcohol 5b in high yield and excellent selectivity, which yielded optically pure 1b in high yield after six steps. Three other D- threo-PDMP analogues with various amine groups have been synthesized using the same methodology, including the more potent pyrrolidine compound D- threo-PDPP (1e). A key feature of the synthesis is the isolation of tosylate (8b), which allows for the divergent synthesis of many analogues from a common advanced intermediate. The synthesis is amenable to large-scale production of D-threo-PDMP, L-threo-PDMP, and similar compounds.

Conjugate Addition of Chloride to α,β-Unsaturated Chiral Imides Promoted by BCl3-derivatives. A Synthesis of 3-Chlorobutanoic Acid

The conjugate addition of chloride to chiral but-2-enoic imides promoted by BCl3-derivatives proceeds with diastereoisomeric ratios of up to 90 : 10 and affords the corresponding 3-chlorobutanoic imides from which, after mild hydrolysis, the 3-chlorobutan

Preparation of Oxazolidin-2-ones by Oxidation of Oxazolidine-2-thiones. A Proton Magnetic Resonance Structural Study

The preparation of a series of oxazolidine-2-thiones, both homochiral and racemic, as well as their oxidation to oxazolidin-2-ones is reported.X-Ray and pmr studies have showed that the stereochemical integrity of the starting aminoalcohol is maintained.