193545-66-3

Basic information

• Product Name: (1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol
• Synonyms: (1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol
• CAS NO: 193545-66-3
• Molecular Weight: 236.314
• Mol File: 193545-66-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol(193545-66-3)
• EPA Substance Registry System: (1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol(193545-66-3)

Safety Data

• Hazardous Substances Data: 193545-66-3(Hazardous Substances Data)

Upstream product

• 903546-28-1 benzyl L-threo-1-hydroxy-3-morpholino-1-phenylpropan-2-yl-carbamate hydrochloride 
• 193545-64-1 benzyl L-threo-1-hydroxy-3-morpholino-1-phenylpropan-2-yl-carbamate 
• 110-91-8 morpholine 
• 175415-16-4 (1S,2S)-2-benzyloxycarbonylamino-1-phenyl-1,3-propanediol-3-methanesulfonyl ester 
• 167082-56-6 tert-butyl [(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]carbamate 
• 148903-85-9 tert-butyl (4S,5S)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-oxazolidine-3-carboxylate 
• 100-58-3 phenylmagnesium bromide 
• 218766-18-8 Toluene-4-sulfonic acid (4S,5S)-2-oxo-5-phenyl-oxazolidin-4-ylmethyl ester 
• 131472-79-2 (1S,2S)-1-phenyl-amino-3-O-tertbutyldimethylsilyloxy-1-propanol 
• 146985-90-2 (4S,5S)-4-hydroxymethyl-5-phenyloxazolidin-2-one 
• 131472-78-1 (1S,2S)-2-[N-(diphenylmethylene)amino]-3-O-(tert-butyldimethylsilyl)-1-phenylpropane-1,3-diol 
• 131751-46-7 (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one 
• 218766-19-9 (4S,5S)-4-Morpholin-4-ylmethyl-5-phenyl-oxazolidin-2-one 
• 207278-86-2 (4S,5S)-2,2-Dimethyl-4-morpholin-4-ylmethyl-5-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 109760-77-2 L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol 

Relevant articles and documents

METHODS FOR TREATING CHRONIC PAIN USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES,3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using the following compounds:

METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from a cognitive disorder using the following compounds (I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII).

Amino alcohol derivative and method for preparing the same

A process for preparing a 2-acylamino alcohol derivative which comprises (A) reacting an aminopropanol derivative represented by the following formula (1): Y—CH2—C*H (NHP1)—C*H(OH)—R1??(1) with an amine represented by R2H to synthesize an amino alcohol derivative represented by the following formula (2): R2—CH2—C*H(NHP1)—C*H(OH)—R1??(2) (B) leaving P1from said amino alcohol derivative represented by formula (2) to synthesize an amino alcohol derivative represented by the following formula (3): R2—CH2—C*H(NH2)—C*H(OH)—R1??(3) (C) reacting said amino alcohol derivative represented by formula (3) with a carboxylic acid represented by R11COOH or a reactive derivative thereof to prepare a 2-acylamino alcohol derivative represented by the following formula (4): R2—CH2—C*H(NHCOR11)—C*H(OH)—R1??(4 ) wherein * represents an asymmetric carbon atom, and P1, R1, R2and R11are defined in the specification. A process for preparing alcohol derivatives having an acylamino group through several steps from amino group-protected 2-aminopropanol derivatives, and novel amino alcohols useful as intermediates in the process for preparing the alcohol derivative.