193545-66-3

Upstream product

• 207278-86-2 (4S,5S)-2,2-Dimethyl-4-morpholin-4-ylmethyl-5-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 131751-46-7 (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one 
• 100-58-3 phenylmagnesium bromide 
• 148903-85-9 tert-butyl (4S,5S)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-oxazolidine-3-carboxylate 
• 167082-56-6 tert-butyl [(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]carbamate 
• 528523-45-7 tert-butyl (1S,2S)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate 
• 110-91-8 morpholine 
• 175415-16-4 (1S,2S)-2-benzyloxycarbonylamino-1-phenyl-1,3-propanediol-3-methanesulfonyl ester 
• 903546-28-1 benzyl L-threo-1-hydroxy-3-morpholino-1-phenylpropan-2-yl-carbamate hydrochloride 
• 193545-64-1 benzyl L-threo-1-hydroxy-3-morpholino-1-phenylpropan-2-yl-carbamate 
• 218766-18-8 Toluene-4-sulfonic acid (4S,5S)-2-oxo-5-phenyl-oxazolidin-4-ylmethyl ester 
• 131472-79-2 (1S,2S)-1-phenyl-amino-3-O-tertbutyldimethylsilyloxy-1-propanol 
• 146985-90-2 (4S,5S)-4-hydroxymethyl-5-phenyloxazolidin-2-one 
• 131472-78-1 (1S,2S)-2-[N-(diphenylmethylene)amino]-3-O-(tert-butyldimethylsilyl)-1-phenylpropane-1,3-diol 

Downstream Products

• 109760-77-2 L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol 

Relevant academic research and scientific papers

METHODS FOR TREATING COGNITIVE DISORDERS USING 1-ARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 1-HETEROARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from a cognitive disorder using compounds of the following formula, Formula (2), wherein the variables have the meaning defined in the specification.

METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from a cognitive disorder using the following compounds (I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII).

METHODS FOR TREATING CHRONIC PAIN USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES,3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using the following compounds:

METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.

Amino alcohol derivative and method for preparing the same

A process for preparing a 2-acylamino alcohol derivative which comprises (A) reacting an aminopropanol derivative represented by the following formula (1): Y—CH2—C*H (NHP1)—C*H(OH)—R1??(1) with an amine represented by R2H to synthesize an amino alcohol derivative represented by the following formula (2): R2—CH2—C*H(NHP1)—C*H(OH)—R1??(2) (B) leaving P1from said amino alcohol derivative represented by formula (2) to synthesize an amino alcohol derivative represented by the following formula (3): R2—CH2—C*H(NH2)—C*H(OH)—R1??(3) (C) reacting said amino alcohol derivative represented by formula (3) with a carboxylic acid represented by R11COOH or a reactive derivative thereof to prepare a 2-acylamino alcohol derivative represented by the following formula (4): R2—CH2—C*H(NHCOR11)—C*H(OH)—R1??(4 ) wherein * represents an asymmetric carbon atom, and P1, R1, R2and R11are defined in the specification. A process for preparing alcohol derivatives having an acylamino group through several steps from amino group-protected 2-aminopropanol derivatives, and novel amino alcohols useful as intermediates in the process for preparing the alcohol derivative.

Amino alcohol derivative and method for preparing the same

Amino alcohol derivatives with a primary amino group or a substituted amino group influence the synthesis of glycolipids and have antiviral, antitumor, metastasis inhibiting and neural cell growth enhancing functions. The amino alcohol derivatives are useful in preparing 2-acylamino alcohol derivatives.

Practical synthesis of threo-(1S, 2S)- and erythro-(1R, 2S)-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) from L-serine

Both L-threo and D-erytho-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) were synthesized stereoselectively from L-serine.

Glycosyltransferase inhibitors: Synthesis of D-threo-PDMP, L-threo- PDMP, and other brain glucosylceramide synthase inhibitors from D- or L- serine

The synthesis of enantiomerically pure (1S,2S)-1-phenyl-2- decanoylamino-3-N-morpholino-1-propanol (L-threo-PDMP) (1a) from L-serine, and the enantiomer (LR,2R)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP] (1b) from D-serine is reported. Reductive alkylation of the fully protected O'Donnell's Schiff base (3b) derived from D-serine provided the β-amino alcohol 5b in high yield and excellent selectivity, which yielded optically pure 1b in high yield after six steps. Three other D- threo-PDMP analogues with various amine groups have been synthesized using the same methodology, including the more potent pyrrolidine compound D- threo-PDPP (1e). A key feature of the synthesis is the isolation of tosylate (8b), which allows for the divergent synthesis of many analogues from a common advanced intermediate. The synthesis is amenable to large-scale production of D-threo-PDMP, L-threo-PDMP, and similar compounds.