146986-45-0Relevant academic research and scientific papers
Design and synthesis of carbohydrate based medium sized sulfur containing benzannulated macrocycles: Applications of Sonogashira and Heck coupling
Hussain, Altaf,Yousuf, Syed Khalid,Sharma, Deepak K.,Mallikharjuna Rao,Singh, Baldev,Mukherjee, Debaraj
, p. 5517 - 5524 (2013/07/05)
Palladium catalyzed intramolecular Sonogashira and Heck coupling reactions have been applied for diversity-oriented synthesis of sulfur containing carbohydrate based medium sized ring macrocycles. The process involves design and synthesis of building bloc
Syntheses and conformational studies on AZT and its deuterated analogues
Gurjar,Kunwar,Reddy,Islam,Lalitha,Jagannadh,Rama Rao
, p. 4373 - 4382 (2007/10/02)
The NMR spectrum of 3′-azido-3′-deoxythymidine (AZT) in aqueous solution provides sum of some of the proton-proton coupling constants. This limitation precludes the determination of the pseudorotational parameters of the sugar ring. Selective deuteration alleviates this problem. The synthesis of 2′-deutero and 3′-deutero- AZT have been described for the first time starting from D-xylose and β-thymidine respectively. NMR study of these analogues in aqueous solutions shows that almost equal amount of C-2′-endo and C-3′-endo species exist in equilibrium.
