1470004-77-3

Upstream product

• 591-50-4 iodobenzene 
• 100747-44-2 dimethyl 2,3-butadienylmalonate 
• 120506-39-0 (4-(bromomethyl)phenoxy) (tert-butyl) dimethylsilane 

Downstream Products

• 1470004-68-2 dimethyl 6-hydroxy-4-(1-phenylvinyl)-3,4-dihydronaphthalene-2,2(1H)-dicarboxylate 

Relevant academic research and scientific papers

Palladium-catalyzed intramolecular ipso-friedel-crafts allylic alkylation of phenols via arylative activation of allenes

A novel and efficient synthetic method for functionalized spiro[4.5]cyclohexadienones was developed based on the palladium-catalyzed sequential process: Heck insertion to an allene-intramolecular ipso-Friedel-Crafts allylic alkylation cascade. Using 5 mol% of palladium catalyst, a wide variety of spirocycles was obtained in good to excellent yields. The developed cascade process was also applicable to the synthesis of tetrahydronaphthalene derivatives. Copyright

Formal meta-specific intramolecular Friedel-Crafts allylic alkylation of phenols through a spirocyclization-dienone-phenol rearrangement cascade

Formal meta-specific intramolecular Friedel-Crafts allylic alkylation of phenols was achieved based on spirocyclization-dienone-phenol rearrangement cascades. Systematic screening of acid catalysts revealed that Sc(OTf) 3 was a highly effective catalyst for dienone-phenol rearrangement of spiro[4.5]cyclohexadienones. Using 5 mol % of Sc(OTf)3 as the promoter, various spirocyclic substrates were transformed into the corresponding phenol derivatives in good to excellent yield. Furthermore, the one-pot sequential spirocyclization-dienone-phenol rearrangement proceeded using a palladium and scandium multi-catalytic system or a triphenylmethyl cation single-catalyst system, providing the corresponding meta-allylated phenol derivatives in excellent yield.