147022-35-3Relevant academic research and scientific papers
Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation
Cho, Hyungdo,Cho, Seung Hwan,Jang, Minjae,Jeong, Jongheon,Kim, Hyunseok,Lee, Eunsung,Lim, Soobin
supporting information, p. 7387 - 7392 (2020/10/12)
Transition-metal-catalyzed transformations of the carbon-fluorine bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein we report a practical cobalt-catalyzed silylation of aryl fluorides that uses a cheap electrophilic silicon source with magnesium. This method is compatible with various silicon sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic silicon source.
Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers
Artico,Stefancich,Silvestri,Massa,Apuzzo,Artico,Simonetti
, p. 693 - 699 (2007/10/02)
Some 1-arylmethylimidazoles bearing a naphthyl group at the α position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antim
