14703-72-1

Basic information

• Product Name: 2-(methylamino)-4-nitrophenol
• Synonyms: 2-(methylamino)-4-nitrophenol
• CAS NO: 14703-72-1
• Molecular Weight: 168.152
• Mol File: 14703-72-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(methylamino)-4-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methylamino)-4-nitrophenol(14703-72-1)
• EPA Substance Registry System: 2-(methylamino)-4-nitrophenol(14703-72-1)

Safety Data

• Hazardous Substances Data: 14703-72-1(Hazardous Substances Data)

Upstream product

• 3889-13-2 5-nitro-3H-benzooxazol-2-one 
• 70886-35-0 N-(2-hydroxy-5-nitrophenyl)formamide 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 74-88-4 methyl iodide 
• 101084-60-0 3-methyl-5-nitrobenzo[d]oxazol-2(3H)-one 

Downstream Products

• 191352-28-0 tert-butyl (2-hydroxy-5-nitrophenyl)(methyl)carbamate 
• 191352-31-5 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-[2-({4-[bis-(2-chloro-ethyl)-amino]-phenoxycarbonyl}-methyl-amino)-4-nitro-phenoxy]-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 191352-27-9 (2S,3S,4S,5R,6S)-6-[2-({4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonyl}-methyl-amino)-4-nitro-phenoxy]-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid 
• 191352-32-6 (2S,3S,4S,5R,6S)-6-[2-({4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonyl}-methyl-amino)-4-nitro-phenoxy]-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 191352-29-1 (2S,3R,4S,5S,6S)-2-(2-((tert-butoxycarbonyl)(methyl)amino)-4-nitrophenoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 191352-30-4 (2S,3S,4S,5R,6S)-2-(methoxycarbonyl)-6-(2-(methylamino)-4-nitrophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 

Relevant articles and documents

Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): A phenol nitrogen mustard carbamate

A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-(ortho-hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed lo

GLUCURONIDE PRODRUGS OF TOFACITINIB

The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula (I): (Formula (I)) where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.

Prodrugs for the therapy of tumors and inflammatory disorders

Compounds of the formula Iglycosyl-Y[--C( Y)--X--] p --W(R) n --Z--C( Y)-active compound (I)are described which are suitable for the treatment of carcinomatous diseases, autoimmune diseases and chronic inflammatory diseases such as rheumatoid arthritis.