Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): A phenol nitrogen mustard carbamate

DOI: 10.1016/S0960-894X(97)00157-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1071 - 1076 (1997)

Update date:2022-07-30

Topics:

Authors:

Schmidt Schmidt

Florent Florent

Monneret

Straub Straub

Czech Czech

Gerken Gerken

Bosslet Bosslet

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Article abstract of DOI:10.1016/S0960-894X(97)00157-1

A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-(ortho-hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed lo

Full text of DOI:10.1016/S0960-894X(97)00157-1

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Product name:2-(methylamino)-4-nitrophenol

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