Bioorganic and Medicinal Chemistry Letters p. 1071 - 1076 (1997)
Update date:2022-07-30
Topics:
Schmidt
Florent
Monneret
Straub
Czech
Gerken
Bosslet
A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-(ortho-hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed lo
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