147056-06-2Relevant academic research and scientific papers
The efficiency of C-4 substituents in activating the β-lactam scaffold towards serine proteases and hydroxide ion
Mulchande, Jalmira,Martins, Luisa,Moreira, Rui,Archer, Margarida,Oliveira, Tania F.,Iley, Jim
, p. 2617 - 2626 (2008/03/13)
The presence of a leaving group at C-4 of monobactams is usually considered to be a requirement for mechanism-based inhibition of human leukocyte elastase by these acylating agents. We report that second-order rate constants for the alkaline hydrolysis an
Orally active β-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution
Hagmann,Kissinger,Shah,Finke,Dorn,Brause,Ashe,Weston,Maycock,Knight,Dellea,Fletcher,Hand,Osinga,Davies,Doherty
, p. 771 - 777 (2007/10/02)
The effect of changing the C-4 substituent of 3,3-diethyl-1- [(benzylamino)carbonyl]-2-azetidinone on inhibition of HLE and in a model of HLE-induced lung damage in hamsters was explored. Substituents at this position do not appear to interact strongly with HLE with the most potent compounds having k(obs)/[I] = 6900 M-1 s-1. However, substituents at this position had a marked effect on in vivo activity. The greatest oral activity in the lung hemorrhage assay was achieved with C-4 aryl carboxylic acid ethers (60-85% inhibition at 30 mg/kg po). Based upon the established mechanism of inhibition by these compounds, the C-4 substituent would be released, and therefore, the pharmacological potential of these C-4 substituents was of considerable concern. Fortunately, compounds containing 4-hydroxybenzoic acid and 4-hydroxyphenylacetic acid ethers at C-4 were among the most active analogs. These phenolic acids are also found as urinary metabolites in healthy humans. Other heteroaryls at C-4 were also orally active in this model despite relatively modest enzyme activity.
