147059-75-4 Usage
Description
7-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid, also known as Trovafloxacin mesylate, is a fluorinated quinolone antibacterial agent. It is a white solid that was developed by Pfizer under the brand name Trovan. Trovafloxacin mesylate works by inhibiting the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 μg/ml) and DNA gyrase (IC50 = 7.13 μg/ml). However, it was withdrawn from the market due to the risk of liver failure.
Uses
1. Used in Antimicrobial Applications:
Trovafloxacin mesylate is used as a broad-spectrum antibiotic, effective against various bacterial infections. It inhibits bacterial DNA replication, transcription, and repair by blocking the activity of essential enzymes such as DNA gyrase and topoisomerase IV.
2. Used in Toxicity Assays:
Trovafloxacin mesylate has been utilized as a test compound in toxicity assays to evaluate its toxicity in 2D hepatocyte cultures. This helps in understanding the potential side effects and safety concerns associated with its use.
3. Used in Apoptosis Research:
Trovafloxacin mesylate has also been employed to study and manipulate the mechanism of apoptotic cell disassembly during apoptosis. This contributes to the understanding of cell death processes and may aid in the development of new therapeutic strategies for various diseases.
Please note that the provided materials do not mention any uses of Glycerol. The example given for Gallotannin is not relevant to the compound in question, which is Trovafloxacin mesylate.
Therapeutic Function
Antibacterial
Biological Activity
Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria.
Biochem/physiol Actions
Trovafloxacin mesylate acts as a pannexin1 (Panx1) inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 147059-75-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,0,5 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 147059-75:
(8*1)+(7*4)+(6*7)+(5*0)+(4*5)+(3*9)+(2*7)+(1*5)=144
144 % 10 = 4
So 147059-75-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16+;
