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Usage

Uses

Used in Pharmaceutical Industry:
H-ORN(FMOC)-OH is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its role in peptide synthesis allows for the creation of complex bioactive peptides, which can be used as potential drug candidates for various therapeutic applications.
Used in Biochemical Research:
H-ORN(FMOC)-OH is used as a research tool in biochemical studies, particularly in the investigation of peptide synthesis and the urea cycle. Its presence as a protected amino acid allows researchers to study the effects of different peptide sequences on biological processes.
Used in Agricultural Industry:
H-ORN(FMOC)-OH is used as a component in the development of biopesticides and other agricultural chemicals. The bioactive peptides synthesized using this reagent can be tested for their potential to control pests and diseases in crops, contributing to sustainable agriculture practices.
Used in Cosmetics Industry:
H-ORN(FMOC)-OH is used as an ingredient in the formulation of cosmetic products. The bioactive peptides derived from its use in peptide synthesis can be incorporated into skincare and hair care products, offering potential benefits such as anti-aging, skin repair, and hair growth promotion.

Upstream product

• 70-26-8 L-ornithine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 3184-13-2 L-ornithine hydrochloride 

Relevant academic research and scientific papers

Decomposition of copper-amino acid complexes by oxalic acid dihydrate

A facile approach to the synthesis of some side-chain-protected amino acids via oxalic acid dihydrate as the copper sequestering reagent is presented. The copper in the amino acid complex reacted with oxalic acid dihydrate to form insoluble cupric oxalate, with the free amino acid released. Compared with conventional methods, this method is convenient, inexpensive, and environmentally friendly.

Decomposition of copper-amino acid complexes by sodium sulfide

Sodium sulfide very efficiently removes copper from protected amino acid-copper complexes. The copper in the amino acid complex was reduced to insoluble cuprous sulfide and the free amino acid was released in pure form. This method is very convenient and rapid, requiring only 5-10 min and 0.55-0.75 equiv of sodium sulfide.

Epimerization of peptide nucleic acids analogs during solid-phase synthesis: Optimization of the coupling conditions for increasing the optical purity

Peptide nucleic acid (PNA) analogs based on Nα-(thymin-1-ylacetyl)ornithine were previously shown to form triplexes with complementary RNA. In order to obtain optically pure compounds for hybridization experiments, chiral monomers based on D- or L-ornithine, Nδ-Fmoc-Nα-(thymin-1-ylacetyl)ornithine 2 and Nδ-Fmoc-Nα (uracil-1-ylacetyl)ornithine 3 were synthesized either by a one-step or by a simple three-step procedure starting from Nδ-protected ornithine; the latter procedure led to enantiomerically pure products. Oligomerization of 2 and 3 was carried out either in solution, or by solid-phase peptide synthesis (SPPS) on an MBHA-Rink amide resin. The oligomers turned out to contain large amounts of epimerization products, especially those obtained by SPPS. Therefore, we examined carefully the parameters which may be involved in epimerization: the nature of the coupling reagent, of the base, and the addition mode. Coupling of the monomer L-3 was performed under various conditions. Lower racemization was found to occur when using (7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU) as coupling agent and 2,4,6-trimethylpyridine (sym-collidine, TMP) as base, without preactivation, leading to a residual 4% of the D-enantiomer. By applying a procedure based on the stepwise addition of the base the D-enantiomer content was reduced to less than 1%. Using this procedure, a decamer of L-3 was synthesized, which was shown to contain less than 2% of the D-ornithine derivative.