147088-66-2Relevant academic research and scientific papers
Unanticipated participation of HCl in nucleophilic chlorination reaction: Expedient route to meta chlorophenols
Chittimalla, Santhosh Kumar,Bandi, Chennakesavulu
supporting information, p. 15 - 19 (2015/12/23)
o-Quinone monoketals participated in a 1,4-addition reaction with HCl furnishing m-chlorophenols in high yields. Several readily available o-quinone monoketals were selected to display the generality of this serendipitous and unprecedented reaction and the results are presented herein.
Access to 3-arylindoles through a tandem one-pot protocol involving dearomatization, a regioselective michael addition reaction, and rearomatization
Chittimalla, Santhosh Kumar,Bandi, Chennakesavulu,Putturu, Sireesha,Kuppusamy, Rajesh,Boellaard, Kevin Christopher,Tan, David Chu Aan,Lum, Demi Ming Jie
, p. 2565 - 2575 (2014/05/06)
A facile, general and rapid protocol for the introduction of oxygenated aryls at the 3-position of indoles is described. This approach consists of a tandem dearomatization, a regioselective Michael addition reaction, and rearomatization in a one-pot three-step sequence to obtain 3-arylindoles in good yields. A non-metal mediated detour method for installing oxygenated aryls at the 3-position of indoles is described. Copyright
A detour route for meta functionalization of phenols
Chittimalla, Santhosh Kumar,Kuppusamy, Rajesh,Bandi, Chennakesavulu
, p. 1991 - 1996 (2014/11/08)
Cyclohexadienones participate in a two-step procedure, a Michael addition followed by aromatization, providing hitherto difficult-to-synthesize meta-functionalized phenol derivatives in good yield. Application of the developed approach is exemplified by synthesizing C-aryl acetophenones, C-aryl glycines, and elemicin - an allylphenol natural product. Georg Thieme Verlag Stuttgart · New York.
[3+2] Cycloaddition of masked o-benzoquinones with azomethine ylides
Chittimalla, Santhosh Kumar,Kuppusamy, Rajesh,Chakrabarti, Anjan
experimental part, p. 1901 - 1906 (2012/09/22)
A simple and efficient access to highly functionalized isoindolone derivatives via a [3+2] cycloaddition process between in situ generated azomethine ylides with various stable (isolable) masked o-benzoquinones is described. This approach allows a rapid and general synthesis of isoindolones with substituents to further manipulate and elaborate the structural complexity. Georg Thieme Verlag Stuttgart · New York.
Oxidation with hypervalent iodine reagents. Part II: Novel cyclohexadienones as precursors for the synthesis of anthraquinones
Mitchell, Anthony S.,Russell, Richard A.
, p. 4387 - 4410 (2007/10/03)
The oxidation of substituted phenols with phenyliodonium diacetate in methanol was found to afford 2,4-cyclohexadienones, 2,5-cyclohexadienones or mixtures of isomers, depending on the substrate being oxidized. Annulation of these cyclohexadienones with the anion of 3-cyanophthalide afforded anthraquinones in high yields.
Oxidations Of Substituted Phenols With Hypervalent Iodine : Applications To The Phthalide Annulation Route To Anthraquinones
Mitchell, Anthony S.,Russell, Richard A.
, p. 545 - 548 (2007/10/02)
Substituted phenols are oxidized by phenyliodonium diacetate in methanol to yield either cyclohexa-2,4-dienones or the isomeric 2,5-dienones depending upon the structure of the phenol.Annulation of these oxidation products with the anion of 3-cyanophthali
