1471-18-7Relevant academic research and scientific papers
Cluster mannosides as inhibitors of type 1 fimbriae-mediated adhesion of Escherichia coli: Pentaerythritol derivatives as scaffolds
Lindhorst, Thisbe K.,Dubber, Michael,Krallmann-Wenzel, Ulrike,Ehlers, Stefan
, p. 2027 - 2034 (2000)
Pentaerythritol derivatives were used as core molecules for the synthesis of two cluster α-D-mannosides, which were designed as oligomannoside mimetics. The problem of glycosyl orthoester formation, which frequently occurs in oligo-mannosylations, was solved. The clusters were tested for their capacity to block binding of Escherichia coli to yeast mannan in vitro and were found to be more than 200 times more potent in inhibiting mannose-specific adhesion than methyl α-D-mannoside.
Syntheses and phase-transfer properties of dendritic nanocarriers that contain perfluorinated shell structures
Garcia-Bernabe, Abel,Kraemer, Michael,Olah, Bela,Haag, Rainer
, p. 2822 - 2830 (2004)
Perfect dendrimers that contain perfluorinated shells have recently attracted attention because they have been shown to encapsulate polar molecules in supercritical CO2 and catalytically active metal nanoparticles in perfluorinated solvents. Moreover, they can then be easily separated after reaction from the biphasic organic/fluorous system. In this paper several dendritic architectures that contain perfluorinated shells were derived by covalent modification of glycerol dendrimers ([G0.5]-[G3.5]), hyperbranched polyglycerol, and polyethyleneimine. These core-shell architectures show interesting physicochemical properties. For example, they are soluble in fluorinated solvents, they are able to transport different guest molecules, and they display thermomorphic behavior. The transport capacity of these molecular nanocarriers increases significantly when amino groups are present in the core. Certain functionalized polyethyleneimines that contain perfluorinated shells show high transport capacities (up to 3 dye molecules per nanocarrier) in perfluorinated solvents. Moreover, these perfluoro-functionalized dendritic polyethyleneimines can act as templates that stabilize nanoparticles; for example, encapsulation and subsequent chemical reduction of AgI ions. Silver nanoparticles with a narrow size distribution (3.9 ± 1 nm) have been prepared and characterized by transmission electron microscopy. Furthermore, it has been demonstrated that the encapsulated guest molecules remain accessible to small molecules after transport into the fluorous phase. Therefore, dendritic nanocarriers that contain perfluorinated shells are currently being investigated as polar environments in nonpolar reaction media such as fluorous phases and supercritical CO2, in particular, for application in homogenous catalysis.
The effect of polyglycerol sulfate branching on inflammatory processes
Paulus, Florian,Schulze, Ronny,Steinhilber, Dirk,Zieringer, Maximilian,Steinke, Ingo,Welker, Pia,Licha, Kai,Wedepohl, Stefanie,Dernedde, Jens,Haag, Rainer
, p. 643 - 654 (2014)
In this study, the extent to which the scaffold architecture of polyglycerol sulfates affects inflammatory processes and hemocompatibility is investigated. Competitive L-selectin binding assays, cellular uptake studies, and blood compatibility readouts are done to evaluate distinct biological properties. Fully glycerol based hyperbranched polyglycerol architectures are obtained by either homopolymerization of glycidol (60% branching) or a new copolymerization strategy of glycidol with ethoxyethyl glycidyl ether. Two polyglycerols with 24 and 42% degree of branching (DB) are synthesized by using different monomer feed ratios. A perfectly branched polyglycerol dendrimer is synthesized according to an iterative two-step protocol based on allylation of the alcohol and subsequent catalytic dihydroxylation. All the polyglycerol sulfates are synthesized with a comparable molecular weight and degree of sulfation. The DB make the different polymer conjugates perform different ways. The optimal DB is 60% in all biological assays.
Synthesis and Properties of Two Tetrapus Host Molecules with Fluorinated Chains
Wang, Jian-She,Zhang, Han-Zhong,Huang, Wei-Yuan,Jiang, Xi-Kui
, p. 10459 - 10466 (1994)
Two tetrapus molecules, 1a and 1b, were synthesized.They each possess fluorinated tentacles with anionic termini, i.e., CH2O(CH2)3(CF2)2O(CF2)2SO3-,Na+ for 1a and CH2O(CH2)3(CF2)4O(CF2)2SO3-,Na+ for 1b.Cationic and anionic naphthalene fluorescence probes with CH2CH2O(CH2)10-chains (FP+ and FP-) were used to study host-guest interactions between partners of the following pairs, i.e., 1a and FP+, 1a and FP-, 1b and FP+, 1b and FP-.Our results demonstrate that electroststic attraction is a powerful factor in facilitating the host-guest interactions between the tetrapus and the long-chain probes.
Preparation method of pentaerythritol triallyl ether
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Paragraph 0036-0052, (2020/06/16)
The invention provides a preparation method of pentaerythritol triallyl ether and particularly relates to the technical field of synthesis of pentaerythritol triallyl ether. The method is characterized by comprising the following steps: S1, under normal pressure, feeding pentaerythritol, pentaerythritol triallyl ether, tetrabutylammonium bromide and 50% sodium hydroxide aqueous solution into a stirring reaction kettle, and heating the mixture to dissolve pentaerythritol into liquid; S2, dropwise adding chloropropene, keeping chloropropene and water evaporated, and layering the chloropropene and water after condensation, and returning chloropropene to the stirring reaction kettle; and S3, after the reaction is finished, adding water, and cooling and standing the mixture for layering, and carrying out reduced pressure distillation on the upper organic phase to obtain the product pentaerythritol triallyl ether. According to the preparation method of pentaerythritol triallyl ether providedby the invention, pentaerythritol triallyl ether is adopted as a solvent during synthesis, the addition of an inert solvent in the existing process is optimized and removed, rectification recycling or environment-friendly treatment measures of the inert solvent are not needed, and high-pressure operation of taking water as the solvent is avoided, so that the reaction is beneficial to the generation of pentaerythritol triallyl ether.
Crosslinking agent (by machine translation)
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Paragraph 0097; 0099, (2018/12/12)
PROBLEM TO BE SOLVED: To provide a crosslinking agent exhibiting excellent performance as a crosslinking agent and hardly volatilizing to outside the system after compounding. SOLUTION: The crosslinking agent includes an organoboron compound having three or more partial structures (I) represented by formula (I) in the molecule. In the formula, m is 0 or 1; n is an integer of 1-3; R1and R2are each independently a hydrogen atom or an alkyl group which may be substituted; and R1and R2may be connected to each other. COPYRIGHT: (C)2012,JPO&INPIT
BIO-NANO POWER CELLS AND THEIR USES
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Paragraph 0496; 0497; 0498; 0500; 0501; 0502, (2014/01/08)
The present invention concerns bio-nano power cells and methods of their manufacture and use. More particularly, the present invention relates to the preparation of bio-nano power cells that are biocompatible and capable of producing flash, intermittent, or continuous power by electrolyzing compounds in biological systems.
Total synthesis of high loading capacity PEG-based supports: Evaluation and improvement of the process by use of ultrafiltration and PEG as a solvent
Turgis, Raphael,Billault, Isabelle,Acherar, Samir,Auge, Jacques,Scherrmann, Marie-Christine
, p. 1016 - 1029 (2013/07/25)
The present work deals with the total synthesis of high loading capacity PEG supports with attention focused on improving the greenness of all the steps. The systematic calculation of green metrics offers an opportunity to evaluate the greenness and then to improve the process. To evidence such an improvement, the evaluation of the optimized processes was compared with that of the classical ones.
PEHAM DENDRIMERS FOR USE IN AGRICULTURE
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Page/Page column 44-45, (2011/05/11)
Specific PEHAM dendrimers are used in a formulation with an active agent for agricultural purposes, particularly for increasing the efficacy of the active agent in various ways, such as by improving solubility of the active agent in the formulation, by improving adhesion and penetration of the active agent to plant surfaces, by improving the water- fastness of the active agent to the plant or seed, by providing protection of the active agent from UV damage, by increasing soil penetration of the active agent to reach the plant roots or under soil parts, or by reducing soil adhesion of the active agent to reach the plant roots or under soil parts, or reducing enzymatic degradation of the active agent by the plant or seed or microorganisms in the soil.
DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
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Page/Page column 74-76, (2010/11/24)
Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
