14711-06-9

Upstream product

• 917-64-6 methyl magnesium iodide 
• 14377-33-4 3,5-di-tert-butylbenzoyl chloride 
• 14665-97-5 2-(3,5-Di-tert-butylphenyl)-2-propanol 
• 85313-44-6 t-Bumeoc-L-Phe-OH 
• 116916-07-5 bis<1-(3,5-di-tert-butylphenyl)-1-methylethyl>diazine 
• 116916-09-7 2-(3,5-di-tert-butylphenyl)-2-(dimethylamino)propane 

Downstream Products

• 14665-80-6 1,3-di-tert-butyl-5-isopropylbenzene 
• 42053-02-1 2,2-Dimethyl-4-(3,5-di-tert.-butyl)phenylpentan-4d 

Relevant academic research and scientific papers

Remote steric effects on the disproportionation / recombination ratio of cumyl radicals

The disproportionation / combination ratio in the reaction between two 3,5-di-tert-butylcumyl radicals, generated by thermolysis of the corresponding diazene, is 0.21 +/- 0.03 at 60 deg C in benzene.This is much larger than the value of 0.06 found for the unsubstituted cumyl radicals.It is suggested that the tert-butyl groups hinder the formation of a parallel association complex, which has been proposed to account for the much smaller amount of disproportionation in the reaction between benzylic radicals as compared with alkyl radicals.

The 1-(3,5-Di-tert-butylphenyl)-1-methylethoxycarbonyl (t-Bumeoc) Residue, a Protecting Group Cleavable under Extremely Mild Acidic Conditions

The synthesis of 1-(3,5-di-tert-butylphenyl)-1-methylethoxycarbonyl fluoride (8) and its reaction with selected amino acids as well as the 13C NMR spectroscopic characterization of t-Bumeoc derivatives are described.The new protecting group is cleavable under very mild acidic conditions.The kinetics of the cleavage is studied by high-performance liquid chromatography (HPLC).The utility of the t-Bumeoc compared to the Adpoc protecting group is demonstrated taking a derivative of the molluscan neuropeptide as an example.