147123-49-7

Basic information

• Product Name: 3-amino-N-phenylthiophene-2-carboxamide
• Synonyms: 3-amino-N-phenylthiophene-2-carboxamide
• CAS NO: 147123-49-7
• Molecular Weight: 218.279
• Mol File: 147123-49-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-amino-N-phenylthiophene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-N-phenylthiophene-2-carboxamide(147123-49-7)
• EPA Substance Registry System: 3-amino-N-phenylthiophene-2-carboxamide(147123-49-7)

Safety Data

• Hazardous Substances Data: 147123-49-7(Hazardous Substances Data)

Upstream product

• 1029280-25-8 (2-phenylcarbamoylthiophen-3-yl)carbamic acid tert-butyl ester 
• 55341-87-2 3-aminothiophene-2-carboxylic acid 
• 62-53-3 aniline 
• 137844-98-5 3-aminothiophene-2-carbohydrazide 
• 147123-50-0 thieno<3,2-d>-1,2,3-triazin-4(3H)-one 

Downstream Products

• 1029280-26-9 3-(2-chloropropionylamino)thiophene-2-carboxylic acid phenylamide 
• 1029280-31-6 3-[(2-chlorobutanoyl)amino]-N-phenylthiophene-2-carboxamide 
• 147123-52-2 3-phenylthieno<3,2-d>-1,2,3-triazin-4(3H)-one 

Relevant articles and documents

Visible-light-induced denitrogenative phosphorylation of benzotriazinones: A metal- And additive-free method for accessing: Ortho -phosphorylated benzamide derivatives

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B2pin2 instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS

The current invention provides compounds of formula (1): wherein: one of Q1, Q2 and Q3 is S, and the other of two of Q1, Q2 and Q3 are -CR1-, which are inhibitors of PI3K-delta. These compounds are useful for treatment of conditions mediated by PI3K-delta, such as hematopoietic cancers, immune disorders, and bone resorption disorders. The invention further provides pharmaceutical compositions comprising a compound of formula (1) and methods of using these compounds and compositions to treat conditions mediated by PI3K-delta.