147129-10-0Relevant academic research and scientific papers
ENZYMES IN ASYMMETRIC SYNTHESIS: EFFECT OF REACTION MEDIA ON THE PLE CATALYSED HYDROLYSIS OF DIESTERS
Guanti, Giuseppe,Banfi, Luca,Narisano, Enrica,Riva, Renata,Thea, Sergio
, p. 4639 - 4642 (1986)
Organic cosolvents and other addenda can influence the rate and the enantioselectivity of pig liver esterase catalysed hydrolysis of meso diacetates and diesters, the magnitude of the effect being strongly dependent on the nature of substrate.
Regio- and stereoselective transacylation of polyhydric alcohols using pronase in organic solvents
Bhattacharya, A,Ali, E
, p. 898 - 899 (2007/10/02)
Pronase a mixture of proteases from Streptomyces griseus has been found to be a good catalyst for transacylation in organic solvents.With equimolar concentrations of p-nitrophenyl acetate as acyl donor in pyridine, aliphatic diols give predominantly the monoacetates.Glucose and isomeric hexoses give the 6-O-acetates in good yield. 6-Deoxy-sugars however, yield mixtures of acetates indicating that regioselectivity among the secondary hydroxyl groups are poor.Racemic trans-1,2-cyclohexanediol affords the (1R, 2R)-monoacetate in 44percent yield with greater than 90percent enantiomer ic purity. cis-1,2-cyclohexanediol and cis-1,2-cyclohexanedimethanol also give optically active monoacetates.
