98516-00-8

Upstream product

• 1687-29-2 dimethyl cis-1,2-cyclohexanedicarboxylate 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 15753-50-1 cis-1,2-cyclohexanedimethanol 
• 108-24-7 acetic anhydride 

Downstream Products

• 103261-98-9 1-Methylene-2-(acetoxymethyl)cyclohexane 
• 2819-48-9 1,2-bis(methylene)cyclohexane 
• 98516-09-7 Acetic acid (1R,2S)-2-hydroxymethyl-cyclohexylmethyl ester 
• 147129-10-0 Acetic acid 2-hydroxymethyl-cyclohexylmethyl ester 

Relevant academic research and scientific papers

(2-Vinylcyclopropyl)carbenes. More stepwise mechanisms for ring-expansion

A simple vinyl group is sufficient to induce a stepwise mechanism for the ring expansion of cyclopropylcarbenes.

Evidence for 2-Hexene-1,6-diyl Diradicals Accompanying the Concerted Diels-Alder Cycloaddition of Acrylonitrile with Nonpolar 1,3-Dienes

The spontaneous reactions of a series of alkyl 1,3-dienes with acrylonitrile (AN) were investigated.Reproducible spontaneous copolymerizations were shown to compete with the expected concerted cycloadditions.For dienes which exist in s-cis/s-trans equilibrium, both copolymer and cycloadduct are formed.Kinetic measurements show that the alternating copolymerization and cycloaddition are two independent paralell second order reactions.With 1,3-cyclohexadiene and 1,2-dimethylenecyclohexane, for which s-gauche is in equilibrium with s-cis, copolymerization still competes with cycloaddition.The s-trans-locked verbenene forms only copolymer, while s-cis-locked cyclopentadiene and 1,2-dimethylenecyclopentane form only cycloadduct rapidly.Our explanation involves a 2-hexene-1,6-diradical, formed by combination between the terminal carbons of the s-gauche or s-trans diene and acrylonitrile.This does not cyclize but initiates copolymerization.Competitively s-cis conformer undergoes classical concerted addition.

ENZYMES IN ASYMMETRIC SYNTHESIS: EFFECT OF REACTION MEDIA ON THE PLE CATALYSED HYDROLYSIS OF DIESTERS

Organic cosolvents and other addenda can influence the rate and the enantioselectivity of pig liver esterase catalysed hydrolysis of meso diacetates and diesters, the magnitude of the effect being strongly dependent on the nature of substrate.

Enantioselective hydrolysis of cis-1,2-diacetoxycycloalkanedimethanols: enzymatic preparation of chiral building blocks from prochiral meso-substrates.

The enzymatic hydrolysis of the prochiral title compounds 1a-f in presence of porcine liver esterase (PLE) and lipase from porcine pancreas (PPL) was studied, resulting in the preparation of the chiral monoacetates 2b-f with high (72-99percente.e.) enantiomeric purities.