147134-72-3Relevant academic research and scientific papers
SYNTHESE UND ANTITUMORAKTIVITAET VON PLATIN(II)-KOMPLEXEN MIT CHOLESTERINDERIVATEN
Brunner, H.,Sperl, G.
, p. 935 - 944 (2007/10/02)
Low-density-lipoprotein-receptor binding moieties were introduced into Pt(II) complexes in order to facilitate the selective transport into cancer cells.Cholesterol esters of aminoacids and 2,3-diaminopropionic acid were attached to the PtCl2 fragment via their NH2 groups.Steroidal amine and diamine ligands were synthesized and transformed into the corresponding dichloroplatinum(II) complexes.A steroidal carboxylic acid was prepared and coupled with the Pt(NH3)2 fragment.The antitumor activity of the compounds was tested towards the lymphatic P 388 leukemia of the CD2F1 mouse and towards the human mammary carcinoma cell line MDA-MB 231.The Pt(II) complexes gave a maximum growth inhibition of 54percent.
