147164-48-5

Basic information

• Product Name: Benzenemethanol, 4-fluoro-a-methylene-, acetate
• CAS NO: 147164-48-5
• Molecular Formula: C10H9FO2
• Molecular Weight: 180.179
• Mol File: 147164-48-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-fluoro-a-methylene-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-fluoro-a-methylene-, acetate(147164-48-5)
• EPA Substance Registry System: Benzenemethanol, 4-fluoro-a-methylene-, acetate(147164-48-5)

Safety Data

• Hazardous Substances Data: 147164-48-5(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 41024-58-2 1-(4-fluorophenyl)-2-(phenylsulfonyl)-1-ethanone 
• 1339838-72-0 1-(4'-fluorophenyl)-4,4,4-trifluoro-1-butanone 
• 1449549-55-6 benzyl 4-(4-fluorophenyl)-4-oxo-2-phenylbutanoate 
• 756489-25-5 4-(4-fluoro-phenyl)-4-oxo-butyronitrile 
• 82415-38-1 ethyl 1-hydroxy-2-oxo-1-cyclopentanecarboxylate 
• 172585-57-8 (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester 

Relevant articles and documents

Visible-Light-Promoted Synthesis of α-CF2H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates

An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CF2H-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of fac-Ir(ppy)3, this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CF2H-substituted ketones are successfully created via designed systems based on the SET process. The methodology has also provided an operationally simple process with broad functional group compatibility.

Visible light induced C-H monofluoroalkylation to synthesize 1,4-unsaturated compound

We developed a method to synthesize fluorinated 1,4-unsaturated dicarbonyl compounds via photoredox catalyzed radical addition process. Commercially available ethyl bromodifluoroacetate (BrCF2CO2Et) as fluoroalkyl source, the corresponding fluoro-containing dicarbonyl compounds could be obtained in moderate to good yields.

Ag2CO3-mediated direct functionalization of alkyl nitriles: Facile synthesis of γ-ketonitriles through nitrile alkylation of enol acetates

Direct C(sp3)-H functionalization of alkyl nitriles is a low toxic and facile route to nitrile-containing compounds. In this research, the Ag2CO3-mediated nitrile methylenation of enol acetates is developed to prepare γ-ketonitriles through the direct C(sp3)-H oxidative functionalization of acetonitrile. A radical pathway is proposed, and acetonitrile serves both as solvent and CN-containing radical source.