1472-00-0Relevant articles and documents
3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF
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Paragraph 1390-1391, (2020/02/05)
The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.
SYNTHESIS OF DIACIDS, DIALDEHYDES, OR DIAMINES FROM THF-DIOLS
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Page/Page column 10; 11, (2015/05/05)
A simple and elegant chemical process for the synthesis of oxygenated products, such as acids and aldehydes, or other derivative products, such as amines and nitriles, of cyclic bifunctional molecules made from renewable, bio-based sources such as HMF and
THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS
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Page/Page column 63, (2009/04/24)
The invention relates to thienopyrimidine and pyrazolopyrimidine compounds of the Formulas (Ia) and (IIa), or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein compositions comprising the compounds, and methods for making and using the compounds.
Catalytic hydrogenation of 5-hydroxymethylfurfural in aqueous medium
Schiavo, V.,Descotes, G.,Mentech, J.
, p. 704 - 711 (2007/10/02)
The catalytic hydrogenation of 5-hydroxymethylfurfural (HMF) in aqueous medium was studied in presence of Ni, Cu, Pt, Pd, Ru based catalysts.In neutral aqueous mdeium, two major products are abtained in very good yields: 2,5-bis-hydroxymethylfuran (Cu, Pt, Ru) and 2,5-bis-hydroxymethyltetrahydrofuran-cis (Ni, Pd, Ru).In acidic aqueous medium, hydrogenolysis reactions occur and the hydrogenation of HMF leads to two other products: 1-hydroxyhexane-2,5-dione and hexane-1,2,5-triol, mainly in presence of Pt and Ru.A mechanism of formation of these two compounds is proposed.Key words: 5-hydroxymethylfurfural / hydrogenation / hydrogenolysis
Synthesis of Stereoisomeric Crown Ethers Composed of cis- and trans-2,5-Bis(hydroxymethyl)tetrahydrofuran Units and Their Selective Transport of Alkali Metal Cations through Liquid Membranes
Nakazaki, Masao,Naemura, Koichiro,Makimura, Masaru,Matsuda, Atsushi,Kawano, Takaaki,Ohta, Yoshihiro
, p. 2429 - 2435 (2007/10/02)
Optical resolution of trans-tetrahydrofuran-2,5-dicarboxylic acid (13) was carried out via the (+)-2-(1-aminoethyl)naphthalene salt, and conversion of the (+) enantiomer 13 into (+)-2,5-dimethyltetrahydrofuran (17) of known configuration established its 2R,5R configuration.Condensation of (+)- and (-)-trans-ditosylates 15 and cis-ditosylate 20 with pyrocatechol afforded (-)-D2-trans,trans-8, (-)-C1-cis,trans-9, meso-C2h-trans,trans-10, and a mixture of meso-C2h-11 and meso-C2v-cis,cis crown ethers 12.Their selective transport of alkali metal cations is reported.
