147221-35-0Relevant academic research and scientific papers
Solid-Phase Synthesis of Oxetane Modified Peptides
Beadle, Jonathan D.,Knuhtsen, Astrid,Hoose, Alex,Raubo, Piotr,Jamieson, Andrew G.,Shipman, Michael
supporting information, p. 3303 - 3306 (2017/06/23)
Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C=O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three steps in solution, then integrated into peptide chains by conventional Fmoc SPPS. This methodology is used to make a range of peptides in high purity including backbone modified derivatives of the nonapeptide bradykinin and Met- and Leu-enkephalin.
2-Phenyl isopropyl esters as carboxyl terminus protecting groups in the fast synthesis of peptide fragments
Yue,Thierry,Potier
, p. 323 - 326 (2007/10/02)
The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a fmoc strategy is used to build up peptide fragments.
