147225-65-8

Upstream product

• 136918-14-4 phthalimide 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 7148-03-0 o-tolylbenzoic acid 
• 114772-53-1 2-Cyano-4'-methylbiphenyl 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 

Downstream Products

• 133052-21-8 4'-Aminomethyl-1,1'-biphenyl-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

1-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl} -pyrrolidine-2-carboxamide: Investigation of structural variations

We recently reported a series of 1-acyl-N-(biphenyl-4-ylmethyl)pyrrolidine- 2-carboxamides as AT1 receptor ligands. The most potent compound of the series, 1-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}- pyrrolidine-2-carboxamide, showed an interesting affinity for the receptor. To investigate the influence of structure variations on affinity, the synthesis of additional compounds belonging to this series has been performed. Biological tests run on the newly synthesized compounds on CHO-hAT1 cells stably expressing the human AT1 receptor confirm our previous hypothesis, i.e. that, within this series, the length of the acyl chain, the substitution of the amidic group and the nature of the acidic one are crucial for the receptor interaction, being a valeric chain, a secondary amidic function and the tetrazole moiety, respectively, the optimal ones. New 1-acyl-N-(biphenyl-4- ylmethyl)pyrrolidine-2-carboxamides have been designed by enlarging our previously reported series in order to clarify the requirements for AT 1 receptor interaction. Copyright

Substituted n-biphenylyl lactams

This invention relates to novel N-biphenylyl lactam compounds having a substituted methylidene or methyl moiety adjacent to the lactam nitrogen, and pharmaceutically acceptable salts thereof.The compounds are angiotensin II receptor antagonists, and are u