147226-04-8 Usage
General Description
N-CBZ-4-OXO-D-PROLINE, also known as N-Carboxybenzyl-4-oxo-D-proline, is a chemical compound commonly used as a building block in organic synthesis. It is derived from D-proline, a naturally occurring amino acid, and is commonly synthesized through the protection of the carboxyl group with a benzyl group. N-CBZ-4-OXO-D-PROLINE is utilized in the production of pharmaceuticals, peptides, and other biologically active molecules, due to its ability to serve as a synthetic intermediate in organic chemistry. N-CBZ-4-OXO-D-PROLINE is considered to be an essential component in the development and production of various drugs and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 147226-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,2,2 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 147226-04:
(8*1)+(7*4)+(6*7)+(5*2)+(4*2)+(3*6)+(2*0)+(1*4)=118
118 % 10 = 8
So 147226-04-8 is a valid CAS Registry Number.
147226-04-8Relevant articles and documents
An improved, scalable synthesis of bis-amino acids
Cheong, Jae Eun,Pfeiffer, Conrad T.,Northrup, Justin D.,Parker, Matthew F.L.,Schafmeister, Christian E.
supporting information, p. 4882 - 4884 (2016/10/24)
trans-4-Hydroxy-L-proline derived bis-amino acids are chiral, cyclic building blocks that display two alpha-amino acids that are differentiated from each other with protecting groups. They are assembled into spiroligomers—rigid, shape-programmable spirocyclic oligomers that are both stereochemically and functionally diverse. The synthesis presented here focuses on recent improvements that allow for a convenient, large-scale synthesis of twelve stereochemically pure bis-amino acids from inexpensive trans-4-hydroxy-L-proline. The bis-amino acids differ in stereochemistry as well as the amine protecting group, one of which (para-nitrobenzyl carbamate) has not been previously incorporated into bis-amino acids.
