147228-26-0Relevant academic research and scientific papers
Organocatalytic preparation of simple β-hydroxy and β-amino esters: Low catalyst loadings and gram-scale synthesis
Jiang, Hao,Gschwend, Bjoern,Albrecht, Lukasz,Anker Jorgensen, Karl
supporting information; experimental part, p. 5052 - 5055 (2010/12/25)
A combined amino- and N-heterocyclic carbene (NHC)-catalyzed one-pot reaction sequence for the synthesis of simple enantioenriched β-hydroxy and β-amino esters using commercially available catalysts at low catalyst loadings has been developed. The desired
An enantiospecific synthesis of β-amino acids
Jefford,Wang
, p. 1111 - 1114 (2007/10/02)
L-Aspartic acid by regioselective modification of the α-carboxylic acid group, namely N-tosylation, anhydride formation, reduction, iodo-esterification, alkylation, and deprotection afforded a series of γ-alkyl β-aminobutyric acids of the R configuration (ee > 99%).
Enantiospecific syntheses of indolizidines 167B and 209D
Jefford, Charles W.,Wang, Jian Bo
, p. 3119 - 3122 (2007/10/02)
Indolizidine 209D (2) was synthesized in 11 steps from L-aspartic acid (3) in an overall yield of 16%. 3R-pyrrolylnonanoic acid, prepared from 3, was converted into the α-keto diazomethyl derivative, which on Rh2(OAc)4-catalyzed cycl
