14723-88-7

Upstream product

• 6645-42-7 N-benzyloxycarbonyl-L-phenylalanine-(N'-phenyl-hydrazide) 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 100-63-0 phenylhydrazine 

Downstream Products

• 116097-76-8 Z-Asp(OCH₃)-Phe-NH-NH-Ph 
• 116097-78-0 Z-Asp(OC₂H₅)-Phe-NH-NH-Ph 
• 97458-31-6 benzyloxycarbonyl-γ-carboxyglutamyl-phenylalanine phenylhydrazide 
• 81378-51-0 {(S)-2-(4-Hydroxy-phenyl)-1-[(R)-1-({[(S)-2-phenyl-1-(N'-phenyl-hydrazinocarbonyl)-ethylcarbamoyl]-methyl}-carbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid benzyl ester 
• 14746-09-9 N-Benzyloxycarbonyl-Phe-Phe-phenylhydrazid 
• 14723-91-2 N-Benzyloxycarbonyl-Leu-Phe-phenylhydrazid 
• 14723-90-1 N-Benzyloxycarbonyl-Gly-Phe-phenylhydrazid 
• 753006-19-8 3-((2S,4S)-4-Benzyl-2-methyl-5-oxo-1-phenylamino-imidazolidin-2-yl)-propionic acid ethyl ester 
• 75525-25-6 (S)-2-Amino-3-(4-hydroxy-phenyl)-N-[(R)-1-({[(S)-2-phenyl-1-(N'-phenyl-hydrazinocarbonyl)-ethylcarbamoyl]-methyl}-carbamoyl)-ethyl]-propionamide 
• 97458-34-9 γ-carboxyglutamyl-phenylalanine 
• 97458-33-8 benzyloxycarbonyl-γ-carboxyglutamyl-phenylalanine 
• 14721-35-8 Gly-Phe-phenylhydrazid 

Relevant academic research and scientific papers

Green synthesis of new chiral 1-(arylamino)imidazo-[2,1-a]isoindole-2,5-diones from the corresponding α-amino acid arylhydrazides in aqueous medium

New chiral 1-(arylamino)imidazo[2,1-a]isoindole-2,5-dione derivatives were obtained in good to excellent yields via the cyclocondensation of 2-formylbenzoic acid and various α-amino acid arylhydrazides using water as the solvent in the presence of sodium

Synthesis of new chiral bis-imidazolidin-4-ones: Comparison between the classic method and green chemistry conditions

Novel bis-imidazolidin-4-ones were synthesized in moderate to good yields through the cyclocondensation of o-, m-and p-phthalaldehydes with various substituted phenylhydrazides. These nitrogenated cyclic compounds were prepared via green chemistry conditi

Enantioseparation of Sulfoxides and Nitriles by Inclusion Crystallization with Chiral Organic Salts Based on l-Phenylalanine

Enantioselective inclusion of aromatic sulfoxides and nitriles was achieved in a host framework created by organic salts comprising achiral benzoic acids and a chiral primary amine (1a) derived from l-phenylalanine. Tuning of the combined achiral acid component successfully changed the chiral recognition ability of the organic salts. The guest molecules were hydrogen-bonded to form three-component inclusion crystals, and the enantiomers of nitriles and sulfoxides were separated with high selectivity up to 92 and 98 % ee. As far as we know, this is the first example of the enantioseparation of non-functionalized aromatic nitriles.

Enantiopure Schiff bases of amino acid phenylhydrazides: Impact of the hydrazide function on their structures and properties

A rapid and eco-friendly synthesis of new enantiopure Schiff bases 5a-e was performed from various α-amino acid phenylhydrazides and 2-hydroxynaphthaldehyde using microwave or ultrasound irradiation in yields ranging from 57 to 75%. These imines were char

A convenient procedure for the synthesis of chiral 6,7-dihydroxy-1- phenylamino-dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-diones

The cyclocondensation reactions between l-α-amino acid phenylhydrazides and 2,3-O-isopropylidene-l-erythruronolactone in the presence of a catalytic amount of p-toluenesulfonic acid afforded diastereomerically pure (3S,6R,7R,7aS)-3-substituted-6,7-isoprop

Solvent-free synthesis of new chiral 3-phenylamino-3,5-dihydro-4h-imidazol- 4-one derivatives from α-amino acid phenylhydrazides

Enantiopure 2,5-disubstituted 3-phenylamino-3,5-dihydro-4Himidazol- 4-one derivatives were obtained in good to excellent yields by condensation of chiral α-amino acid phenylhydrazides and triethyl orthoesters in the presence of dry acetic acid as catalyst

New heterocycles from the reaction between some natural α-amino acid hydrazides and formaldehyde

The ring forming condensation between some natural α-amino acid phenylhydrazides (1) and aqueous formaldehyde (2) has opened a novel synthetic route to hexahydro-1,2,4-triazin-6-one derivatives (3). Polycyclic systems were obtained from the same reaction carried out with L-aspartic acid 1,4-bis(2-phenylhydrazide) (1d), L-histidine phenylhydrazide (1e) and L- tryptophan phenylhydrazide (1f) which gave perhydro-4,6-dioxo-2,8- diphenyl[1,2,4]triazino[4,5-d][1,2,4]triazepine (5) perhydro-1-oxo-3- phenylimidazo[5,4-d][1,2,4]triazino[4,5-a]pyridine (7) and 1,2,3-H-3-(2- phenylcarbazoyl)-β-carboline (8), respectively. Substrates 1 were conveniently obtained by direct reaction of phenylhydrazine with L-α-amino acid esters retaining the original chirality.