1472613-49-2Relevant academic research and scientific papers
Asymmetric synthesis of chiral dihydrothiopyrans via an organocatalytic enantioselective formal thio [3 + 3] cycloaddition reaction with binucleophilic bisketone thioethers
Wang, Shengzheng,Zhang, Yongqiang,Dong, Guoqiang,Wu, Shanchao,Zhu, Shiping,Miao, Zhenyuan,Yao, Jianzhong,Li, Hao,Li, Jian,Zhang, Wannian,Sheng, Chunquan,Wang, Wei
, p. 5570 - 5573 (2013)
An unprecedented organocatalytic highly enantioselective approach to a 3,4-dihydro-2H-thiopyran scaffold with two contiguous stereogenic centers has been implemented through a formal thio [3 + 3] cycloaddition process involving a Michael-aldol condensation cascade sequence. Notably, a new class of binucleophilic bisketone thioethers is designed for the process. Furthermore, the fine-tuning of their reactivity enables the cascade process to proceed with highly regioselectively.
