147266-79-3

Basic information

• Product Name: (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID
• Synonyms: (2S,4S)-BOC-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID;(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID;(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXYPYRROLIDINE-2-CARBOXYLIC ACID;(2S,4S)-Boc-4-phenoxy-Pro-OH;(4S)-N-Boc-4-phenoxy-L-proline
• CAS NO: 147266-79-3
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.34
• Mol File: 147266-79-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 455.8°Cat760mmHg
• Flash Point: 229.4°C
• Appearance: /
• Density: 1.235g/cm³
• Vapor Pressure: 4.24E-09mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• PKA: 3.66±0.40(Predicted)
• CAS DataBase Reference: (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID(147266-79-3)
• EPA Substance Registry System: (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID(147266-79-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 147266-79-3(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C16H21NO5/c1-16(2,3)22-15(20)17-10-12(9-13(17)14(18)19)21-11-7-5-4-6-8-11/h4-8,12-13H,9-10H2,1-3H3,(H,18,19)/t12-,13-/m0/s1

Upstream product

• 221050-87-9 N-Boc-cis-4-phenoxy-L-proline benzyl ester 
• 108-95-2 phenol 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 93967-75-0 methyl (1-tert-butoxycarbonyl)-(4S)-phenoxy-(2S)-pyrrolidinylcarboxylate 

Downstream Products

• 1133717-67-5 N-1-Boc-cis-4-phenoxy-L-(2-hydroxyphenyl)pyrrolidine-2-carboxamide 
• 1133717-69-7 N-1-Boc-cis-4-phenoxy-L-(5-methyl-2-hydroxyphenyl)pyrrolidine-2-carboxamide 
• 1133717-71-1 N-1-Boc-cis-4-phenoxy-L-(5-tert-butyl-2-hydroxyphenyl)pyrrolidine-2-carboxamide 
• 317357-20-3 (2S,4S)-1-tert-butoxycarbonyl-4-phenoxy-2-pyrrolidine carbaldehyde 
• 1266099-67-5 (2S,4S)-allyl 2-(hydroxymethyl)-4-phenoxypyrrolidine-1-carboxylate 
• 886447-49-0 ethyl [4-[1-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(4S)-phenoxy-(2S)-pyrrolidinylcarbonyl]-1-piperazinyl]acetate 

Relevant articles and documents

Rationally designed 4-phenoxy substituted prolinamide phenols organocatalyst for the direct aldol reaction in water

A rationally designed 4-phenoxy substituted prolinamide phenols as an efficient hydrophobic organocatalyst for direct asymmetric aldol reaction in water has been developed. High yield (up to 99%), diastereoselectivity (up to 99:1), and enantioselectivity (up to 97%) were obtained under optimal condition. The influence of substituent groups on the reactivity of catalysts was studied in detail. Crown Copyright

NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES

The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)-membered heterocyclyl selected from the group consisting of and wherein R1. R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formulas (I), (II), and (III) and methods of treating a condition that is mediated by the modulation of the 11-β-hsd-1 enzyme, the method comprising administering to a mammal an effective amount of a compound of formulas (I), (II), and (III).