1472660-06-2

Upstream product

• 726193-03-9 (S)-ethyl 3-(1,4-dioxaspiro[4.5]decan-2-yl)propanoate 
• 1472660-04-0 3-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]propanoic acid 

Downstream Products

• 1472660-08-4 (4R)-4-benzyl-3-{(2R)-3-[ (2S)-1,4-dioxaspiro[4.5]dec-2-yl]-2-methylpropanoyl}-1,3-oxazolidin-2-one 
• 1472660-18-6 (2R,4S)-8-(benzyloxy)-2-methyloct-6-yne-1,4-diol 
• 1472660-20-0 (3R,5S)-5-[4-(benzyloxy)but-2-yn-1-yl]-3-methyldihydrofuran-2(3H)-one 
• 1472659-99-6 (3R,5S)-9-(benzyloxy)-3-methylnon-1-en-7-yn-5-ol 
• 1472660-27-7 (3R,5R)-9-(benzyloxy)-3-methylnon-1-en-7-yn-5-yl N-[(tert-butoxy)carbonyl]-N-methyl-D-phenylalaninate 
• 1472660-29-9 (3R,5R)-9-(benzyloxy)-3-methylnon-1-en-7-yn-5-yl N-methyl-D-phenylalaninate 
• 1472660-31-3 (3R,5R)-9-(benzyloxy)-3-methylnon-1-en-7-yn-5-yl N-[(2S,4R)-2,4-dimethylhex-5-enoyl]-N-methyl-D-phenylalaninate 
• 1472660-16-4 (2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate 

Relevant academic research and scientific papers

Synthetic studies toward (+)-spongidepsin

A convergent enantiomerically controlled synthetic effort toward (+)-spongidepsin is reported. The synthesis benefits from the use of readily available and inexpensive starting materials like D-mannitol and (-)-β-citronellene. Key transformations include Evans asymmetric methylation, Mitsunobu esterification, (1H-benzotriazol-1-yloxy) tripyrrolidinophosphonium hexafluorophosphate (PyBOP)-mediated amide formation for the preparation of a fully functionalized acyclic precursor, and ring-closing metathesis (RCM). Copyright