75175-78-9

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-1-(2-Chlorophenyl)-3-(dimethylamino)-prop-2-en-1-one is used as a medication for managing high blood pressure and attention deficit hyperactivity disorder (ADHD). It is effective in reducing blood pressure by stimulating alpha receptors, which leads to a decrease in heart rate and blood vessel constriction. Additionally, it helps in managing ADHD by reducing hyperactivity and impulsivity in affected individuals.
Used in Medical Treatments:
(2E)-1-(2-Chlorophenyl)-3-(dimethylamino)-prop-2-en-1-one is used as a therapeutic agent in various forms, including tablets, patches, and injections. Its versatility in administration allows for tailored treatment plans based on individual patient needs and preferences.

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 147283-46-3 6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 848462-68-0 2-amino-5-(2-chlorobenzoyl)thiazole 
• 1065266-64-9 9-(4-acetylphenyl)-5-tert-butyl-8-(2-chlorophenyl)pyrido[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one 

Relevant academic research and scientific papers

An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes asC4units

An efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the CC bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standardC4units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a CC bond cleavage of the enaminone and insertion of a newC(sp2) source with the formation of two C-C single bonds. A broad range of substrates can be used to synthesize the corresponding 1,3-dienes under very mild reaction conditions, including low catalyst-loading, ambient temperature, and a neutral reaction solvent.

Harnessing Stereospecific Z-Enamides through Silver-Free Cp?Rh(III) Catalysis by Using Isoxazoles as Masked Electrophiles

The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom- and step-economic fashion. The stereochemistry of enamides might originate from the relative disposition of atoms present in isoxazole and the intramolecular hydrogen bonding. The reaction showed excellent scope as several structurally and electronically diverse salicylaldehydes and isoxazoles reacted efficiently.

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

The synthesis, SAR and binding affinities are described for cannabinoid-1 receptor (CB1R) specific inverse agonists based on pyridopyrimidine and heterotricyclic scaffolds. Food intake and pharmacokinetic evaluation of several of these compounds indicate

SUBSTITUTED PYRIDO[3,2-E][1,2,4]TRIAZOLO[4,3-C]PYRIMIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in