14731-29-4

Usage

InChI:InChI=1/C8H6ClN3S2/c9-5-1-3-6(4-2-5)10-7-11-12-8(13)14-7/h1-4H,(H,10,11)(H,12,13)

Upstream product

• 125908-39-6 1-butyl-6-(4'-chlorophenyl)-2,5-dithiobiurea 
• 125908-38-5 1-propyl-6-(4'-chlorophenyl)-2,5-dithiobiurea 
• 125908-32-9 1-ethyl-6-(4'-chlorophenyl)-2,5-dithiobiurea 
• 125908-28-3 1-methyl-6-(4'-chlorophenyl)-2,5-dithiobiurea 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 22814-92-2 4-(p-chlorophenyl)-3-thiosemicarbazide 
• 75-15-0 carbon disulfide 

Downstream Products

• 79100-14-4 [5-(4-Chloro-phenylamino)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid ethyl ester 
• 14731-55-6 (4-chloro-phenyl)-(5-methanesulfonyl-[1,3,4]thiadiazol-2-yl)-amine 
• 14731-57-8 (4-chloro-phenyl)-(5-phenylmethanesulfonyl-[1,3,4]thiadiazol-2-yl)-amine 
• 42238-74-4 N-(4-chlorophenyl)-6-chlorobenzo[d]thiazol-2-amine 
• 42238-73-3 N,N'-bis-(4-chloro-phenyl)-[1,3,4]thiadiazole-2,5-diamine 
• 21123-69-3 5-(4-chloro-anilino)-4-(4-chloro-phenyl)-2,4-dihydro-[1,2,4]triazole-3-thione 
• 21123-83-1 5-(4-chloro-anilino)-4-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 21123-56-8 N-(4-chloro-phenyl)-N'-phenyl-[1,3,4]thiadiazole-2,5-diamine 
• 42254-20-6 3-benzylsulfanyl-7-chloro-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole 
• 1276684-05-9 5-p-chlorophenylamino-3-aminomethyl-2-mercapto-1,3,4-thiadiazole 

Relevant academic research and scientific papers

Synthesis and evaluation of new 1,3,4-thiadiazole derivatives as potent antifungal agents

With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a–3l) were synthesized and characterized. Due to thione-thiol tautomerism in the intermediate compound 2, type of subst

Synthesis and antifungal activities of ω-(5-arylamino-1,3,4-thiadiazol-2-thio)-ω(1H-1,2,4-triazol-1-yl) acetophenones

Several ω-(5-arylamino-1,3,4-thiadiazol-2-thiol)-ω-(1H-1,2,4-triazol-1- yl)acetophenones 4a-i have been synthesized. The representative compounds exhibit some antifungal and plant growth regulatory activities. The structures of these compounds have been confirmed by elemental analyses, 1H NMR, IR and MS spectra.

an interesting isomerization: synthesis of mesoionic 5-arylamino-1,3,4-thiadiazolium-2-thiolates by using ω-bromo-ω-(1H-1,2,4-triazol-1-yl)acetophenone as catalyst

Mesoionic 5-arylamino-1,3,4-thiadiazolium-2-thiolates 7a-f were prepared by the isomerization of 5-arylamino-1,3,4-thiadiazol-2-thiones 5a-f by using ω-bromo-ω-(1H-1,2,4-triazol-1-yl)acetophenone 6 as catalyst. All the structures of mesoionic synthesized were confirmed by elemental analyses, 1H NMR, IR and MS spectral data. We have also determined the x-ray photoelectron spectroscopy (XPS) of the mesoionic and their precursors. A comparison of XPS spectra between the mesoionic and their precursors showed that the charge separation in mesoionic is distinctly larger than in their precursors.

Alkali catalyzed thermal cyclization of 1-substituted and 1,6-disubstituted 2,5-dithiobiureas: Formation of 1,2,4-triazolidine-3,5-dithiones and/or 1,3,4-thiadiazoline-5-thiones

Alkali catalyzed thermal cyclization of 1-alkyl and 1,6-dialkyl-2,5-dithiobiureas (I, R=alkyl, R'=H and R=R'=alkyl) results in the formation of 4-alkyl-1,2,4-triazolidine-3,5-dithiones (V) (alkyl=Me or Et) and 2-alkylamino-Δ2-1,3,4-thiadiazoline-5-thiones (VI) (alkyl=n-Pr or n-Bu).Under the same conditions, 1-alkyl-6-aryl-2,5-dithiobiureas (I, R=alkyl, R'=aryl) give 2-arylamino-Δ2-1,3,4-thiadiazoline-5-thiones (IX) (alkyl=Me, Et, n-Pr or n-Bu) and 4-alkyl-1,2,4-triazolidine-3,5-dithiones (V) also when the alkyl groups are Me or Et.