14731-39-6

Basic information

• Product Name: 4-(but-3-ynyl)morpholine
• Synonyms: 4-(but-3-ynyl)morpholine;4-(but-3-yn-1-yl)morpholine
• CAS NO: 14731-39-6
• Molecular Formula: C₈H₁₃NO
• Molecular Weight: 139.19492
• Mol File: 14731-39-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 63 °C(Press: 3 Torr)
• Appearance: /
• Density: 0.973±0.06 g/cm3(Predicted)
• PKA: 6.40±0.10(Predicted)
• CAS DataBase Reference: 4-(but-3-ynyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(but-3-ynyl)morpholine(14731-39-6)
• EPA Substance Registry System: 4-(but-3-ynyl)morpholine(14731-39-6)

Safety Data

• Hazardous Substances Data: 14731-39-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 23418-85-1 3-butyn-1-yl p-toluenesulfonate 
• 72486-09-0 methanesulfonic acid but-3-ynyl ester 

Downstream Products

• 267243-54-9 4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine 
• 267243-53-8 6-amino-4-[N-(3-chloro-4-fluorophenyl)amino]-7-[(1E)-4-(4-morpholinyl)-1-butenyl]pyrido[3,2-d]pyrimidine 
• 267243-55-0 6-amino-4-[N-(3-chloro-4-fluorophenyl)amino]-7-[4-(4-morpholinyl)butyl]pyrido[3,2-d]pyrimidine 
• 1188490-23-4 (2S,3S,4R)-(5E,7E)-3-(4-methoxybenzyloxy)-2,4,6-trimethyl-10-morpholinodeca-5,7-dien-1-ol 
• 912353-71-0 C₂₆H₂₆ClFN₄O₂ 
• 544707-24-6 4-[4-(4-(piperidin-1-ylmethyl)phenyl)but-3-ynyl]morpholine 
• 1188547-06-9 4-[4-(3-(piperidin-1-ylmethyl)phenyl)but-3-ynyl]morpholine 
• 37183-13-4 1,2-bis(phenylselanyl)ethane 
• 267243-52-7 4-[N-(3-chloro-4-fluorophenyl)amino]-6-fluoro-7-[(1E)-4-(4-morpholinyl)-1-butenyl]pyrido[3,2-d]pyrimidine 

Relevant articles and documents

Synthesis of camphecene derivatives using click chemistry methodology and study of their antiviral activity

A series of seventeen tetrazole derivatives of 1,7,7-trimethyl-[2.2.1]bicycloheptane were synthesized using click chemistry methodology and characterized by spectral data. Studies of cytotoxicity and in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells of the compounds obtained were performed. The structure-activity relationship analysis suggests that to possess virus-inhibiting activity, the compounds of this group should bear oxygen atom with a short linker (C2-C4), either as a hydroxyl group (18, 19, 29), keto-group (21) or as a part of a heterocycle (24). These compounds demonstrated low cytotoxicity along with high anti-viral activity.

Nickel-catalyzed sonogashira reactions of non-activated secondary alkyl bromides and iodides

A nicked reaction: The title reaction of terminal alkynes with non-activated secondary alkyl iodides and bromides was accomplished for the first time. This reaction provides a new and practical approach for the synthesis of substituted alkynes (see scheme; cod=cyclo-1,5-octadiene). Copyright

Manganese- or iron-catalyzed homocoupling of grignard reagents using atmospheric oxygen as an oxidant

Atmospheric oxygen was used for the first time as an oxidant in metal-catalyzed homocoupling of Grignard reagents. These manganese- or iron-catalyzed reactions are efficient, cheap, and eco-friendly. They are applicable to the large-scale synthesis of symmetrical conjugated compounds. Copyright